Hypothalamic inflammation is reversed by endurance training in anorectic-cachectic rats

Nutrition & Metabolism

Table 2 Leptin mRNA and protein expression in the RPAT and MEAT rats

RPAT	MEAT
Gene expression (U.A)
SC	0.76 ± 0.17	1.03 ± 0.13
ST	0.74 ± 0.18	0.65 ± 0.05*
SPF	*4.40 ± 1.80#@**	0.80 ± 0.05
EC	0.46 ± 0.12	0.64 ± 0.11
ET	0.76 ± 0.04	0.36 ± 0.06
EPF	1.06 ± 0.20	0.52 ± 0.15
Protein expression (ng.mg tissue)
SC	1.20 ± 0.17	0.202 ± 0.02
ST	0.63 ± 0.067*	0.042 ± 0.02*
SPF	0.63 ± 0.08*	*0.044 ± 0.01@**
EC	1.45 ± 0.15@	0.250 ± 0.05
ET	1.18 ± 0.36@#	0.141 ± 0.009#
EPF	0.95 ± 0.040	0.174 ± 0.03

Results are expressed as mean value ± SEM. SC: sedentary control (n = 7), ST: sedentary tumour-bearing (n = 7), SPF: sedentary pair-fed (n = 7), EC: trained control (n = 6), ET: trained tumour-bearing (n = 6), EPF: trained pair-fed (n = 6). *p < 0.01 vs. sedentary control; #p < 0.001 vs. sedentary pair-fed. *p < 0.001 significantly different from control values.
# p < 0.001 significantly different from sedentary tumour values.
@ p < 0.001 significantly different from exercise pair-fed values.

ISSN: 1743-7075