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Table 6 Metabolic outcomes: changes from baseline to six and thirty weeksa

From: Mitigating preventable chronic disease: Progress report of the Cleveland Clinic's Lifestyle 180 program

Factor

Units

Change at week six

(N = 392)

Change at week thirty

(N = 295)

  

Mean ± SD

P value b

Mean ± SD

P value b

Glucose

(mg/dL)

-6.3 ± 24.3c

< 0.001

-4.5 ± 29.6e

0.009

 

(mmol/L)

-0.35 ± 1.35

 

-0.25 ± 1.64

 

Triglycerides

(mg/dL)

-27.7 ± 53.8

< 0.001

-26.4 ± 58.5

< 0.001

 

(mmol/L)

-0.31 ± 0.61

 

-0.30 ± 0.66

 

Cholesterol

(mg/dL)

-21.7 ± 25.9

< 0.001

-9.0 ± 29.5

< 0.001

 

(mmol/L)

-0.56 ± 0.67

 

-0.23 ± 0.76

 

HDL

(mg/dL)

-2.0 ± 6.8

< 0.001

3.7 ± 8.4

< 0.001

 

(mmol/L)

-0.05 ± 0.17

 

0.10 ± 0.22

 

LDL

(mg/dL)

-14.3 ± 21.6d

< 0.001

-7.9 ± 25.1

< 0.001

 

(mmol/L)

-0.37 ± 0.56

 

-0.20 ± 0.65

 

HgbA1c

(%)

N/A

N/A

-0.2 ± 0.6f

< 0.001

Insulin

(microU/dL)

-4.4 ± 9.7

< 0.001

-3.8 ± 11.0

< 0.001

 

(pmol/L)

-30.7 ± 67.4

 

-26.6 ± 76.4

 

US-CRP

(mg/mL)

-1.4 ± 6.4

< 0.001

-0.9 ± 4.8

0.012

 

(nmol/L)

-11.9 ± 54.0

 

-7.3 ± 40.2

 
  1. Abbreviations: HDL, high-density lipoprotein cholesterol; LDL, low-density lipoprotein cholesterol; HgbA1c, hemoglobin A1c; US-CRP, ultra sensitive c-reactive protein. N/A, no required measurement at six weeks.
  2. a N = 250, 173 for insulin and N = 270, 198 for US-CRP since neither measured before June 2009.
  3. b P value from the paired t-test, significant if P < 0.025.
  4. c, d, e, f indicate 9, 1, 3, and 24 missing data points, respectively.