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Table 6 Metabolic outcomes: changes from baseline to six and thirty weeksa

From: Mitigating preventable chronic disease: Progress report of the Cleveland Clinic's Lifestyle 180 program

Factor Units Change at week six (N = 392) Change at week thirty (N = 295)
   Mean ± SD P value b Mean ± SD P value b
Glucose (mg/dL) -6.3 ± 24.3c < 0.001 -4.5 ± 29.6e 0.009
  (mmol/L) -0.35 ± 1.35   -0.25 ± 1.64  
Triglycerides (mg/dL) -27.7 ± 53.8 < 0.001 -26.4 ± 58.5 < 0.001
  (mmol/L) -0.31 ± 0.61   -0.30 ± 0.66  
Cholesterol (mg/dL) -21.7 ± 25.9 < 0.001 -9.0 ± 29.5 < 0.001
  (mmol/L) -0.56 ± 0.67   -0.23 ± 0.76  
HDL (mg/dL) -2.0 ± 6.8 < 0.001 3.7 ± 8.4 < 0.001
  (mmol/L) -0.05 ± 0.17   0.10 ± 0.22  
LDL (mg/dL) -14.3 ± 21.6d < 0.001 -7.9 ± 25.1 < 0.001
  (mmol/L) -0.37 ± 0.56   -0.20 ± 0.65  
HgbA1c (%) N/A N/A -0.2 ± 0.6f < 0.001
Insulin (microU/dL) -4.4 ± 9.7 < 0.001 -3.8 ± 11.0 < 0.001
  (pmol/L) -30.7 ± 67.4   -26.6 ± 76.4  
US-CRP (mg/mL) -1.4 ± 6.4 < 0.001 -0.9 ± 4.8 0.012
  (nmol/L) -11.9 ± 54.0   -7.3 ± 40.2  
  1. Abbreviations: HDL, high-density lipoprotein cholesterol; LDL, low-density lipoprotein cholesterol; HgbA1c, hemoglobin A1c; US-CRP, ultra sensitive c-reactive protein. N/A, no required measurement at six weeks.
  2. a N = 250, 173 for insulin and N = 270, 198 for US-CRP since neither measured before June 2009.
  3. b P value from the paired t-test, significant if P < 0.025.
  4. c, d, e, f indicate 9, 1, 3, and 24 missing data points, respectively.