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Table 1 Metabolic and endocrine characteristics of the study population grouped according to BMI.

From: Serum 25-Hydroxyvitamin D Levels, phosphoprotein enriched in diabetes gene product (PED/PEA-15) and leptin-to-adiponectin ratio in women with PCOS

 

PCOS women (90 subjects)

Controls (40 subjects)

 

Lean

(42)

Overweight/Obese

(48)

p

Lean

(20)

Overweight/Obese

(20)

p

Age (yrs)

24.1 ± 4.6

24.8 ± 4.0

NS

23.9 ± 3.6

25.4 ± 4.6

NS

BMI

22.1 ± 2.6

33.1 ± 5.8

<0.001

22.1 ± 1.6

34.9 ± 4.1

<0.001

25(OH)D (ng/ml)

15.1 ± 7.6

11.1 ± 5.8

0.021

48.9 ± 11.3

10.2 ± 4.7

<0.001

PED/PEA-15

290 ± 102

295 ± 113

0.745

153 ± 29

177 ± 47

0.092

Leptin (ng/ml)

25.8 ± 6.6

40.3 ± 9.1

<0.001

9.9 ± 4.8

29.4 ± 6.6

0.003

Adiponectin (ng/ml)

13.2 ± 5.7

9.4 ± 6.3

<0.001

17.4 ± 3

11.6 ± 2.5

<0.001

Insulin (μUI/ml)

11.9 ± 4.6

17.1 ± 9.4

0.014

7.6 ± 1.9

11.5 ± 2.0

<0.001

Leptin-to-adiponectin ratio

2.5 ± 1.8

5.8 ± 2.7

<0.001

0.6 ± 0.4

2.0 ± 1.7

<0.001

HoMA-IR

2.4 ± 1

3.8 ± 2.2

<0.001

1.4 ± 0.3

2.2 ± 0.3

<0.001

SHBG (nmol/l)

45.7 ± 7.2

41.3 ± 6.9

0.001

69.5 ± 3.1

63.3 ± 10.5

0.016

FAI

4.6 ± 0.8

8.7 ± 3.8

<0.001

0.8 ± 0.2

0.9 ± 0.2

0.05

  1. Data are reported as mean ± SD. BMI, body mass index; 25(OH)D, 25(OH) Vitamin D; PED/PEA-15, PED/PEA-15 abundance; HoMA-IR, homeostasis model assessment of insulin resistance; SHBG, sex hormone binding globulin; FAI, free androgen index; FG, Ferriman-Gallwey. PED/PEA-15 protein levels are expressed as arbitrary units. Fasting 25(OH)D, insulin, PED/PEA-15 protein abundance, leptin, and adiponectin values were not normally distributed and have been logarithmically transformed. Differences between lean and overweight/obese subjects in both PCOS and Control women were analysed by unpaired t test. Controls were age and BMI comparable.
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Nutrition & Metabolism

ISSN: 1743-7075

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