| chow | HF | HF/FO | |||
---|---|---|---|---|---|---|
 | CB 1 +/+ | CB 1 -/- | CB 1 +/+ | CB 1 -/- | CB 1 +/+ | CB 1 -/- |
Subcutaneous fat (g) | 0.9 ± 0.1 | 0.7 ± 0.0 | 2.1 ± 0.3# | 1.1 ± 0.1#* | 2.5 ± 0.4# | 1.4 ± 0.1#* |
Epididymal fat (mg) | 319 ± 40 | 227 ± 19 | 716 ± 113# | 361 ± 34#* | 644 ± 85# | 406 ± 64#* |
Retroperitoneal fat (mg) | 116 ± 17 | 66 ± 6* | 217 ± 33# | 108 ± 7#* | 300 ± 54# | 145 ± 19#* |
Brown fat (mg) | 45 ± 6 | 41 ± 5 | 47 ± 6 | 36 ± 3 | 52 ± 5 | 36 ± 5 |
Mesenteric fat (mg) | 194 ± 18 | 148 ± 12 | 303 ± 36# | 181 ± 11* | 336 ± 47# | 190 ± 14* |
Muscular fat (g) | 0.6 ± 0.0 | 0.5 ± 0.0* | 1.0 ± 0.1# | 0.7 ± 0.0#* | 1.1 ± 0.1# | 0.8 ± 0.0#* |
Organ fat (mg) | 113 ± 15 | 103 ± 14 | 176 ± 28 | 161 ± 15# | 238 ± 30# | 133 ± 14* |
Lean mass (g) | 5.2 ± 0.6 | 4.6 ± 0.1* | 5.0 ± 0.1 | 4.7 ± 0.1 | 5.0 ± 0.1 | 4.7 ± 0.1 |
Plasma metabolites and adipokines | Â | Â | Â | Â | Â | |
Triglycerides (μM) | 333 ± 31 | 245 ± 31 | 277 ± 29 | 275 ± 33 | 240 ± 63 | 183 ± 19 |
Cholesterol (mM) | 1.3 ± 0.2 | 0.9 ± 0.1 | 1.9 ± 0.1# | 1.8 ± 0.1# | 1.4 ± 0.1$ | 1.3 ± 0.1#$ |
Non-esterified fatty acids (μM) | 607 ± 32 | 391 ± 34* | 586 ± 40 | 588 ± 51# | 464 ± 38# | 372 ± 26$ |
Blood glucose (mM) | 9.3 ± 0.5 | 7.7 ± 0.8 | 9.1 ± 0.3 | 7.4 ± 0.4* | 9.0 ± 0.4 | 8.1 ± 0.3 |
Insulin (pg/mL) | 334 ± 53 | 356 ± 86 | 325 ± 39 | 270 ± 64 | 371 ± 82 | 300 ± 84 |
Leptin (ng/mL) | 0.7 ± 0.1 | 0.6 ± 0.1$ | 2.1 ± 0.5#* | 1.0 ± 0.2#* | 2.2 ± 0.5# | 1.7 ± 0.3# |
Adiponectin (μg/mL) | 14.3 ± 1.3 | 18.5 ± 2.4 | 15.4 ± 1.5 | 17.0 ± 2.9 | 18.1 ± 2.2 | 19.1 ± 2.2 |
Resistin (ng/mL) | 2.3 ± 0.2 | 2.5 ± 0.4 | 3.0 ± 0.5 | 2.9 ± 0.3 | 2.1 ± 0.2 | 2.6 ± 0.4 |