Parameter | Lean Control | Obese Control | LV-HPMC | HV-HPMC |
---|---|---|---|---|
Mean food intake (g/day) | 16.7 ± 0.2a | 30.0 ± 1.0d | 24.4 ± 0.6c | 22.6 ± 0.4b |
Meal tolerance test total tAUC (x103)2 | 26.9 ± 1.3 a | 44.7 ± 3.9c | 36.9 ± 2.5b | 33.3 ± 1.8ab |
Fasting plasma glucose (mmol/L)3 | 7.2 ± 0.2a | 27.4 ± 1.5c | 24.6 ± 2.5c | 13.7 ± 1.5b |
% Glycated Hb4 | 6.8 ± 0.3a | 17.0 ± 1.0c | 13.5 ± 1.1b | 8.2 ± 0.4a |
Urinary glucose (mg/24h)3 | 39.8 ± 5.3a | 915.5 ± 152.6c | 517.1 ± 121.7b | 207.6 ± 85.6a |
Urinary β-hydroxybutyrate (μg/24h)3 | 48.4 ± 8.3a | 353.0 ± 75.8c | 201.4 ± 37.2b | 145.5 ± 26.8ab |
Kidney weight, as percentage of body weight (g/100g BW)4 | 0.67 ± 0.01b | 0.79 ± 0.02c | 0.67 ± 0.02b | 0.56 ± 0.01a |
Glucose tolerance test, total AUC (x103)3 | 22.3 ± 0.8a | 74.8 ± 3.0d | 56.6 ± 5.8c | 33.8 ± 2.3b |
Glucose tolerance test, incremental AUC (x103)3 | 6.0 ± 0.7 | 6.8 ± 2.4 | 3.4 ± 2.3 | 3.9 ± 2.5 |
QUICKI3 | 0.288 ± 0.003c | 0.206 ± 0.002a | 0.199 ± 0.002a | 0.218 ± 0.004b |
Non-esterified fatty acids in fasted state (mmol/L)3 | 0.86 ± 0.05a | 1.58 ± 0.11b | 1.74 ± 0.19b | 1.63 ± 0.12b |
Non-esterified fatty acids in fed state (mmol/L)4 | 0.51 ± 0.04a | 0.87 ± 0.04b | 0.96 ± 0.08b | 0.94 ± 0.06b |
Urinary TBARS (ug/24h)3,5 | 3.9 ± 0.5a | 7.6 ± 0.8b | 5.2 ± 0.3a | 4.5 ± 0.3a |
Leptin in fasted state (ng/mL)3 | 2.2 ± 0.1a | 50.8 ± 2.9b | 66.1 ± 8.0c | 52.9 ± 5.0bc |
Adiponectin in fasted state (μg/mL)3 | 36.5 ± 4.2b | 20.3 ± 2.4a | 23.3 ± 3.1a | 56.3 ± 4.3c |
Corticosterone in fed state (ng/mL)4 | 62.7 ± 21.3 | 121.5 ± 26.2 | 75.6 ± 19.7 | 114.6 ± 32.9 |