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Table 1 Measures of food intake, glucose control and plasma adipokines 1

From: Hydroxypropyl methylcellulose, a viscous soluble fiber, reduces insulin resistance and decreases fatty liver in Zucker Diabetic Fatty rats

Parameter Lean Control Obese Control LV-HPMC HV-HPMC
Mean food intake (g/day) 16.7 ± 0.2a 30.0 ± 1.0d 24.4 ± 0.6c 22.6 ± 0.4b
Meal tolerance test total tAUC (x103)2 26.9 ± 1.3 a 44.7 ± 3.9c 36.9 ± 2.5b 33.3 ± 1.8ab
Fasting plasma glucose (mmol/L)3 7.2 ± 0.2a 27.4 ± 1.5c 24.6 ± 2.5c 13.7 ± 1.5b
% Glycated Hb4 6.8 ± 0.3a 17.0 ± 1.0c 13.5 ± 1.1b 8.2 ± 0.4a
Urinary glucose (mg/24h)3 39.8 ± 5.3a 915.5 ± 152.6c 517.1 ± 121.7b 207.6 ± 85.6a
Urinary β-hydroxybutyrate (μg/24h)3 48.4 ± 8.3a 353.0 ± 75.8c 201.4 ± 37.2b 145.5 ± 26.8ab
Kidney weight, as percentage of body weight (g/100g BW)4 0.67 ± 0.01b 0.79 ± 0.02c 0.67 ± 0.02b 0.56 ± 0.01a
Glucose tolerance test, total AUC (x103)3 22.3 ± 0.8a 74.8 ± 3.0d 56.6 ± 5.8c 33.8 ± 2.3b
Glucose tolerance test, incremental AUC (x103)3 6.0 ± 0.7 6.8 ± 2.4 3.4 ± 2.3 3.9 ± 2.5
QUICKI3 0.288 ± 0.003c 0.206 ± 0.002a 0.199 ± 0.002a 0.218 ± 0.004b
Non-esterified fatty acids in fasted state (mmol/L)3 0.86 ± 0.05a 1.58 ± 0.11b 1.74 ± 0.19b 1.63 ± 0.12b
Non-esterified fatty acids in fed state (mmol/L)4 0.51 ± 0.04a 0.87 ± 0.04b 0.96 ± 0.08b 0.94 ± 0.06b
Urinary TBARS (ug/24h)3,5 3.9 ± 0.5a 7.6 ± 0.8b 5.2 ± 0.3a 4.5 ± 0.3a
Leptin in fasted state (ng/mL)3 2.2 ± 0.1a 50.8 ± 2.9b 66.1 ± 8.0c 52.9 ± 5.0bc
Adiponectin in fasted state (μg/mL)3 36.5 ± 4.2b 20.3 ± 2.4a 23.3 ± 3.1a 56.3 ± 4.3c
Corticosterone in fed state (ng/mL)4 62.7 ± 21.3 121.5 ± 26.2 75.6 ± 19.7 114.6 ± 32.9
  1. 1Values represent mean ± SEM, n=10-12, except where noted. Values within a row that do not share a common superscript are significantly different, p<0.05.
  2. 2Measured after one week of feeding of the diets.
  3. 3Measured after five weeks of feeding of the diets.
  4. 4Measured at the end of the feeding trial (6 weeks).
  5. 5n=8.