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Table 4 Insulin secretion capacity during hyperglycemic clamp

From: Jerusalem artichoke and chungkookjang additively improve insulin secretion and sensitivity in diabetic rats

 

Diabetic-CON (n=10)

CKJ (n=10)

HTL (n=10)

CKJ+HTL (n=10)

Normal-CON (n=10)

Serum insulin at basal state

0.72±0.13d

0.84±0.11c

0.69±0.10d

1.07±0.16b

1.36±0.26a*

Serum insulin at first phase (ng/mL)

1.56±0.23d

2.03±0.28c

1.86±0.31c

2.50±0.38b

3.94±0.65a*

Serum insulin at second phase (ng/mL)

1.81±0.31c

2.16±0.35b

1.80±0.28c

2.33±041b

3.76±0.67a*

Area under the curve of insulin (AU)

195.8±25.4d

235.3±34.2c

200.0±28.5d

266.2±32.5b

406.4±65.9a*

Glucose infusion rate (mg/kg bw/min)

8.3±1.2d

9.5±1.2c

9.4±1.2c

13.5±1.5b

25.5±3.4a*

Insulin sensitivity (μmol glucose · min-1 · 100 g-1 per μmol insulin/L)

12.4±1.5c

11.9±1.7c

14.1±1.7bc

15.6±1.8b

18.3±2.6a*

  1. Values are mean±SD. First phase insulin secretion was defined as the average of serum insulin levels at 2 and 5 mins, with second phase at 60, 90 and 120 mins. Insulin sensitivity at hyperglycemic state was calculated as the ratio of glucose infusion rates to steady-state serum insulin levels. Rats in the normal-control (Normal-CON) and diabetic-control (Diabetic-CON) was fed high fat diets while diabetic rats in the CKJ, HTL, and CKJ+HTL groups were provided with high fat diets supplemented with 5% CKJ, 5% HTL, and 5% CKJ+ 5% HTL, respectively.
  2. *Significantly different among the groups at p<0.05 by one-way ANOVA.
  3. a,b,c,dValues in the same row with different superscripts were significantly different in Tukey test at P<0.05.