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Table 4 Insulin secretion capacity during hyperglycemic clamp

From: Jerusalem artichoke and chungkookjang additively improve insulin secretion and sensitivity in diabetic rats

  Diabetic-CON (n=10) CKJ (n=10) HTL (n=10) CKJ+HTL (n=10) Normal-CON (n=10)
Serum insulin at basal state 0.72±0.13d 0.84±0.11c 0.69±0.10d 1.07±0.16b 1.36±0.26a*
Serum insulin at first phase (ng/mL) 1.56±0.23d 2.03±0.28c 1.86±0.31c 2.50±0.38b 3.94±0.65a*
Serum insulin at second phase (ng/mL) 1.81±0.31c 2.16±0.35b 1.80±0.28c 2.33±041b 3.76±0.67a*
Area under the curve of insulin (AU) 195.8±25.4d 235.3±34.2c 200.0±28.5d 266.2±32.5b 406.4±65.9a*
Glucose infusion rate (mg/kg bw/min) 8.3±1.2d 9.5±1.2c 9.4±1.2c 13.5±1.5b 25.5±3.4a*
Insulin sensitivity (μmol glucose · min-1 · 100 g-1 per μmol insulin/L) 12.4±1.5c 11.9±1.7c 14.1±1.7bc 15.6±1.8b 18.3±2.6a*
  1. Values are mean±SD. First phase insulin secretion was defined as the average of serum insulin levels at 2 and 5 mins, with second phase at 60, 90 and 120 mins. Insulin sensitivity at hyperglycemic state was calculated as the ratio of glucose infusion rates to steady-state serum insulin levels. Rats in the normal-control (Normal-CON) and diabetic-control (Diabetic-CON) was fed high fat diets while diabetic rats in the CKJ, HTL, and CKJ+HTL groups were provided with high fat diets supplemented with 5% CKJ, 5% HTL, and 5% CKJ+ 5% HTL, respectively.
  2. *Significantly different among the groups at p<0.05 by one-way ANOVA.
  3. a,b,c,dValues in the same row with different superscripts were significantly different in Tukey test at P<0.05.