Jerusalem artichoke and chungkookjang additively improve insulin secretion and sensitivity in diabetic rats

Nutrition & Metabolism

Table 5 The modulation of islet morphometry

	Diabetic-CON (n=7)	CKJ (n=7)	HTL (n=7)	CKJ+HTL (n=7)	Normal-CON (n=7)
β-cell area (%)	6.4±0.7^b	7.0±0.7^ab	6.6±0.7^b	7.8±0.8^a	5.6±0.7^c*
Individual β-cell size (μm²)	242.4±31.1^a	221.3±25.4^ab	215.6±24.7^b	190.5±25.4^b	182.2±26.8^b*
Absolute β-cell mass (mg)	21.1±2.6^c	23.4±2.7^bc	22.8±2.5^c	26.3±2.8^b	34.6±4.8^a*
BrdU⁺ cells (% BrdU⁺ cells of islets)	0.83±0.10^c	0.95±0.11^b	0.86±0.12^bc	1.15±0.13^a	0.74±0.09^c*
Apoptosis (% apoptotic bodies of islets)	0.73±0.08^a	0.68±0.08^ab	0.65±0.08^b	0.60±0.07^b	0.65±0.10^b*
Ratio of β:α cells	4.6±0.5^b	5.8±0.6^b	5.6±0.6^b	6.3±0.7^a	6.0±0.8^a*

Values are mean±SD. Rats in the normal-control (Normal-CON) and diabetic-control (Diabetic-CON) was fed high fat diets while diabetic rats in the CKJ, HTL, and CKJ+HTL groups were provided with high fat diets supplemented with 5% CKJ, 5% HTL, and 5% CKJ+ 5% HTL, respectively.
^*Significantly different among the groups at p<0.05 by one-way ANOVA.
^a,b,cValues in the same row with different superscripts were significantly different in Tukey test at P<0.05.

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