Vitamin K supplementation does not prevent bone loss in ovariectomized Norway rats

Nutrition & Metabolism

Table 2 Bone characteristics of OVX rats fed with low or high vitamin K for 6 wk¹

	Control² PK:0.14 mg/kg diet	BP² PK:0.14 mg/kg diet	PK 107 mg/kg diet	MK-4 147 mg/kg diet	MK-7 201 mg/kg diet
Body weight, g	329.6 ± 3.6	317.2 ± 4.2	331.9 ± 3.8	330.2 ± 3.9	338.3 ± 4.9
Ultimate Force, N	231.8 ± 17.0^a	433.3 ± 21.0^c	295.0 ± 15.0^ab	245.8 ± 18.8^ab	248.4 ± 16.2^ab
Stiffness, Nmm	163.9 ± 20.1^a	258.8 ± 30.2^b	172.8 ± 17.1^a	156.1 ± 19.4^a	128.9 ± 10.9^a
Femur Ca, mg/g	133.3 ± 1.8^a	152.2 ± 2.2^c	135.2 ± 3.1^a	125.7 ± 2.4^b	128.0 ± 1.4^ab
Serum Ca, mg/L	114.3 ± 0.8^a	108.1 ± 0.7^b	112.3 ± 1.0^a	113.8 ± 0.6^a	113.0 ± 0.8^a
Serum PO4, mg/L	90.9 ± 2.2^a	75.8 ± 1.3^b	87.2 ± 2.4^a	86.9 ± 1.9^a	88.2 ± 2.4^a

¹ Values are means ± SED, n = 16. ² Low vitamin K diet (Harlan Teklad, TD. 97053). ^a,b,c When comparing measures across the five groups, means with different letter subscripts are statistically different, P < 0.05

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