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Table 3 Vitamin K concentrations in serum and bone of OVX rats fed with low or high vitamin K for 6 wk1

From: Vitamin K supplementation does not prevent bone loss in ovariectomized Norway rats

 

Control2

PK:0.14 mg/kg diet

BP2

PK:0.14 mg/kg diet

PK

107 mg/kg diet

MK-4

147 mg/kg diet

MK-7

201 mg/kg diet

Serum

     

PK, nmol/L

0.2 ± 0.3a

0.1 ± 0.3a

238.0 ± 92.2c

0.0 ± 0.2a

1.9 ± 0.9b

MK-4, nmol/L

0.3 ± 0.5a

0.2 ± 0.5a

5.8 ± 2.5b

41.5 ± 17.7d

3.1 ± 1.0c

MK-7, nmol/L

NDa

NDa

NDa

NDa

31.4 ± 22.7b

Tibia

     

PK, pmol/g

13.7 ± 12.5a

20.6 ± 14.0ab

1760.0 ± 581.0c

23.7 ± 21.1ab

13.4 ± 16.3ab

MK-4, pmol/g

NDa

NDa

NDa

62.4 ± 87.0c

1.0 ± 1.7b

MK-7, pmol/g

NDa

NDa

NDa

NDa

16.7 ± 14.0b

  1. 1 Values are means ± SD, n = 16. 2 Low vitamin K diet (Harlan Teklad, TD. 97053). ND: values were below the minimum detectable concentrations of 0.05 nmol/L or 0.05 pmol/g. a,b,c When comparing measures across the five groups, means with different letter subscripts are statistically different, P < 0.05