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Table 3 Vitamin K concentrations in serum and bone of OVX rats fed with low or high vitamin K for 6 wk1

From: Vitamin K supplementation does not prevent bone loss in ovariectomized Norway rats

  Control2 PK:0.14 mg/kg diet BP2 PK:0.14 mg/kg diet PK 107 mg/kg diet MK-4 147 mg/kg diet MK-7 201 mg/kg diet
Serum      
PK, nmol/L 0.2 ± 0.3a 0.1 ± 0.3a 238.0 ± 92.2c 0.0 ± 0.2a 1.9 ± 0.9b
MK-4, nmol/L 0.3 ± 0.5a 0.2 ± 0.5a 5.8 ± 2.5b 41.5 ± 17.7d 3.1 ± 1.0c
MK-7, nmol/L NDa NDa NDa NDa 31.4 ± 22.7b
Tibia      
PK, pmol/g 13.7 ± 12.5a 20.6 ± 14.0ab 1760.0 ± 581.0c 23.7 ± 21.1ab 13.4 ± 16.3ab
MK-4, pmol/g NDa NDa NDa 62.4 ± 87.0c 1.0 ± 1.7b
MK-7, pmol/g NDa NDa NDa NDa 16.7 ± 14.0b
  1. 1 Values are means ± SD, n = 16. 2 Low vitamin K diet (Harlan Teklad, TD. 97053). ND: values were below the minimum detectable concentrations of 0.05 nmol/L or 0.05 pmol/g. a,b,c When comparing measures across the five groups, means with different letter subscripts are statistically different, P < 0.05