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Table 1 Subject characteristics of study population: National Health and Nutrition Examination Surveys (NHANES), 1999-20041

From: Population prevalence, attributable risk, and attributable risk percentage for high methylmalonic acid concentrations in the post-folic acid fortification period in the US

Characteristic Value
All subjects, n 18569
Men, n(%) 9020 (49)
Women, n (%) 9549 (51)
Race-ethnicity  
   Non-Hispanic white, n (%) 8170 (44)
   Non-Hispanic black, n (%) 4351 (23.4)
   Mexican American/Hispanic, n (%) 6048 (32.6)
Age  
   12- < 18 y, n (%) 4546 (24)
   ≥ 60 y, n (%) 4427 (23.8)
Supplement users, n (%) 7681 (41)
Non-supplement users2, n (%) 10888 (59)
Serum creatinine ≥ 130 μmol/L, n (%) 331 (1.8)
Serum vitamin B-12 < 148 pmol/L, n (%) 349 (1.9)
Methylmalonic acid (nmol/L)3 129.3 (99.4, 169.4)
Prevalence of high methylmalonic acid  
   All subjects (%)4 3.1 ± 0.21
   Serum creatinine < 130 μmol/L (%)4 2.7 ± 0.2
  1. 1NHANES 1999-2000, 2001-2002, and 2003-2004 were combined into one analytic data set, 1999-2004. NHANESs 1999-2004 were conducted in the post-folic acid fortification period.
  2. 2Persons who did not take vitamin/mineral supplements 1 month prior to the survey
  3. 3Median and 25th and 75th percentiles. Distribution of serum MMA was not normal
  4. 4Methylmalonic acid concentration > 350 nmol/L. Prevalence mean ± SE