Skip to main content

Advertisement

Table 2 Prevalence and likelihood of having high methylmalonic acid (MMA) in the post-folic acid fortification period: National Health and Nutrition Examination Surveys (NHANES), 1999-20041

From: Population prevalence, attributable risk, and attributable risk percentage for high methylmalonic acid concentrations in the post-folic acid fortification period in the US

Characteristic Prevalence2% OR(95% CI)3 P-Value4 P-Value5
Sex     0.98
   Men (n = 9020) 3.2 1.0 (0.83, 1.19) NS  
   Women (n = 9549)6 3.0 1.0 --  
Race-ethnicity     < 0.0001
   Non-Hispanic white (n = 8170) 3.4 2.48 (1.78, 3.45) < 0.001  
   Non-Hispanic black (n = 4351)6 0.2 1.0 --  
   Mexican American/Hispanic (n = 6048) 3.0 2.77 (1.86, 4.14) 0.0003  
Age     < 0.0001
   < 60 y (n = 14142)6 1.9 1.0 --  
   60 y (n = 4427) 8.3 4.01 (3.26, 4.92) < 0.0001  
Supplement use7     < 0.0001
   Yes (n = 7681)6 2.8 1.0 --  
   No (n = 10888) 3.5 1.82 (1.40, 2.37) < 0.0001  
Serum creatinine8     < 0.0001
   < 130 μmol/L (n = 18238)6 2.7 1.0 --  
   130 μmol/L (n = 331) 34.1 12.6 (8.99, 17.7) < 0.0001  
Serum vitamin B-129     < 0.0001
   < 148 pmol/L (n = 349) 27.6 13.5 (9.29, 19.6) < 0.0001  
   148 pmol/L (n = 18220)6 2.6 1.0 --  
  1. 1n = 18569. NHANES 1999-2000, 2001-2002, and 2003-2004 were combined into one analytic data set, 1999-2004. NHANESs 1999-2004 were conducted in the post-folic acid fortification period. Overall prevalence of serum MMA > 350 nmol/L was 3.1 ± 0.2 (% and SE)
  2. 2Population prevalence of serum MMA > 350 pmol/L was based on weighted sample size
  3. 3Odds ratio and 95% Wald confidence intervals in the multivariate logistic regression analysis
  4. 4Significance in comparison to the referent category within the variable (P for Wald χ2)
  5. 5Overall significance of variable in the logistic regression model (P for Wald χ2)
  6. 6Referent group
  7. 7Persons who took vitamin/mineral supplements 1 month prior to the survey
  8. 8Impaired renal function is defined as having serum creatinine ≥ 130 μmol/L
  9. 9Vitamin B-12 deficiency is defined as having serum vitamin B-12 < 148 pmol/L