Table 1 Effect of HF diet and Kupffer cells reduction on lipid and glucose metabolism parameters in serum

body weight (g)

359 ± 3.4

369 ± 11.2

N.S.

365 ± 6.2

372 ± 8.5

N.S.

adiposity (%)

1.2 ± 0.03

1.4 ± 0.07

N.S.

1.6 ± 0.18^x

1.8 ± 0.06

N.S.

s-FFA

(mmol/l)

starved

0.8 ± 0.1

0.81 ± 0.04

N.S.

0.54 ± 0.04^x

0.46 ± 0.01^y

N.S.

fed

0.27 ± 0.02

0.43 ± 0.02

0.01

0.5 ± 0.03^x

0.67 ± 0.02^y

0.01

s-ketone bodies

(mmol/l)

straved

3.1 ± 0.1

3.2 ± 0.1

N.S.

3.1 ± 0.2

2.8 ± 0.4

N.S.

fed

0.16 ± 0.02

0.34 ± 0.01

0.01

0.5 ± 0.05^x

1.2 ± 0.2^y

0.001

s-TAG (mmol/l)

fed

1.1 ± 0.1

1.0 ± 0.1

N.S.

2.0 ± 0.3^x

0.8 ± 0.1

0.001

s-glucose (mmol/l)

starved

4.3 ± 0.2

4.7 ± 0.3

N.S.

4.6 ± 0.3

4.6 ± 0.2

N.S.

s-insulin

(ng/l)

starved

112 ± 6

125 ± 8

N.S.

126 ± 10^x

161 ± 8^y

0.05

fed

544 ± 29

474 ± 37

N.S.

472 ± 18

467 ± 12

N.S.

OGTT AUC_{180 min}

1168 ± 27

1094 ± 41

N.S.

1305 ± 29^x

1370 ± 15^y

0.063

OGTT glucose 60 min, mM

6.5 ± 0.2

6.4 ± 0.24

N.S.

8.7 ± 0.3^x

9.5 ± 0.21^y

0.05