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Table 1 Effect of HF diet and Kupffer cells reduction on lipid and glucose metabolism parameters in serum

From: Kupffer cells ameliorate hepatic insulin resistance induced by high-fat diet rich in monounsaturated fatty acids: the evidence for the involvement of alternatively activated macrophages

   SD SD + GdCl3 P HF HF + GdCl3 P
body weight (g)   359 ± 3.4 369 ± 11.2 N.S. 365 ± 6.2 372 ± 8.5 N.S.
adiposity (%)   1.2 ± 0.03 1.4 ± 0.07 N.S. 1.6 ± 0.18x 1.8 ± 0.06 N.S.
s-FFA (mmol/l) starved 0.8 ± 0.1 0.81 ± 0.04 N.S. 0.54 ± 0.04x 0.46 ± 0.01y N.S.
  fed 0.27 ± 0.02 0.43 ± 0.02 0.01 0.5 ± 0.03x 0.67 ± 0.02y 0.01
s-ketone bodies (mmol/l) straved 3.1 ± 0.1 3.2 ± 0.1 N.S. 3.1 ± 0.2 2.8 ± 0.4 N.S.
  fed 0.16 ± 0.02 0.34 ± 0.01 0.01 0.5 ± 0.05x 1.2 ± 0.2y 0.001
s-TAG (mmol/l) fed 1.1 ± 0.1 1.0 ± 0.1 N.S. 2.0 ± 0.3x 0.8 ± 0.1 0.001
s-glucose (mmol/l) starved 4.3 ± 0.2 4.7 ± 0.3 N.S. 4.6 ± 0.3 4.6 ± 0.2 N.S.
s-insulin (ng/l) starved 112 ± 6 125 ± 8 N.S. 126 ± 10x 161 ± 8y 0.05
  fed 544 ± 29 474 ± 37 N.S. 472 ± 18 467 ± 12 N.S.
OGTT AUC180 min   1168 ± 27 1094 ± 41 N.S. 1305 ± 29x 1370 ± 15y 0.063
OGTT glucose 60 min, mM   6.5 ± 0.2 6.4 ± 0.24 N.S. 8.7 ± 0.3x 9.5 ± 0.21y 0.05
  1. Fasted animals were deprived of food for 24 hours, fed animals had free access to food. Adiposity was expressed as the ratio of epididymal fat pad weight to the total body weight [(EWAT/b.wt.)*100]. OGTT = oral glucose tolerance test; AUC = cumulative area under the curve for blood glucose over 180 min. P value indicates the significance of GdCl3 treatment within each group; x p < 0.05 HF vs SD; y p < 0.05 HF + GdCl3 vs SD + GdCl3. Data are given as mean ± S.E.M., n = 6; OGTT n = 4.