Kupffer cells ameliorate hepatic insulin resistance induced by high-fat diet rich in monounsaturated fatty acids: the evidence for the involvement of alternatively activated macrophages

Table 3 Effect of HF diet and Kupffer cells reduction on glycogen content in the liver

		SD	SD + GdCl₃	P	HF	HF + GdCl₃	P
glycogen (μmol/g)	starved	12 ± 2.6	65 ± 8.5	0.01	17 ± 1.6	49 ± 8	0.05
	fed + ins	226 ± 13	196 ± 13	N.S.	198 ± 19	110 ± 18	0.01

Animals in "fed + ins" group were provided food ad libitum and 30 min prior decapitation were administered insulin (6 U/kg b.wt.) i.p. The glycogen is expressed in glucose equivalents (μmoles per g wet weight) P value indicates the significance of GdCl₃ treatment within each group; ^y p < 0.05 HF + GdCl₃ vs SD + GdCl₃. Data are given as mean ± S.E.M., n = 6.

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