Liver gene expression [FAS mRNA (A) and CPT1a mRNA (B)] in rats in response to 3-week SD, SD + I, HF, or HF + I diets with or without fluvastatin (0, 4 or 8 mg/kg/day). Rats (7 weeks of age) were fed the SD, SD + I, HF, or HF + I diet for 1 week, and then administered fluvastatin (0, 4, or 8 mg/kg) with the diet daily. The rats were sacrificed 14 days after starting the administration of fluvastatin. Values are the mean ± S.E. of 4 determinations. Fold-increase is expressed by taking the control values obtained from SD-fed animals as 1.0. *p < 0.05, **p < 0.01, ***p < 0.001 versus SD diet-fed control rats; # p < 0.05, ##p < 0.01, ###p < 0.001 versus HF diet-fed control rats.