|
Case definition
|
Yes, with independent validation
|
2
|
| |
Yes, record linkage/self report
|
1
|
| |
No description
|
0
|
|
Representativeness
|
Consecutive cases
|
1
|
| |
Potential for selection bias/not stated
|
0
|
|
Selection of controls
|
Community
|
2
|
| |
Hospital/clinic/school
|
1
|
| |
Potential for selection bias/not stated
|
0
|
|
Definition of controls
|
No family history of autism spectrum disorder
|
2
|
| |
Healthy/other psych/developmental/genetic
|
1
|
| |
disorder
| |
| |
Poorly defined/not stated
|
0
|
|
2. Comparability of cases and controls on the basis of the design
| |
|
Study controls for age
|
1
|
|
Study controls for gender
|
1
|
|
3. Exposure
| | |
|
Ascertainment of exposure
| |
| |
Laboratory blinded to case/control status
|
1
|
| |
Laboratory unblinded/not stated
|
0
|
|
Method of ascertainment same for cases and controls
| |
| |
Yes
|
1
|
| |
No
|
2
|
|
4. Additional criteria for genetic studies
| |
|
a. Consideration of Hardy Weinberg Equilibrium
| |
| |
Yes
|
1
|
| |
No
|
0
|
|
b. Power calculations
| |
| |
Yes
|
1
|
| |
No
|
0
|
|
c. Correction for multiple comparisons
| |
| |
Yes
|
1
|
| |
No
|
0
|
|
d. Adjustment for population stratification
| |
| |
Yes
|
1
|
| |
No
|
0
|
