Table 6 Scores for assessment of quality for genetic studies the Newcastle Ottawa Scale
| Â | Bowers et al. 2011 | Ming et al. 2010 | Buyske et al. 2006 | James et al. 2006 | Rose et al. 2006 | Serajee 2004 | Max Score |
|---|---|---|---|---|---|---|---|
1 Selection | Â | Â | Â | Â | Â | Â | Â |
Case definition | 2 | 2 | 1 | 1 | 1 | 2 | 2 |
Representativeness | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Selection of controls | trios | trios | trios | 0 | 0 | trios | 2 |
Definition of controls | n/a | n/a | n/a | 0 | 0 | n/a | 2 |
2 Comparability | Â | Â | Â | Â | Â | Â | Â |
Control for confounding | n/a | n/a | n/a | 0 | 0 | n/a | n/a |
3 Exposure | Â | Â | Â | Â | Â | Â | Â |
Ascertainment | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Method same cases/controls | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
4 Genetics | Â | Â | Â | Â | Â | Â | Â |
HW equilibrium | 1 | 0 | 1 | 1 | 1 | 1 | 1 |
Power calculations | n/a | 0 | 1 | 0 | 0 | 1 | 1 |
Control multiple comparisons | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Population stratification | n/a | n/a | 0 | 0 | 0 | n/a | 1 |
Overall score | 4 | 3 | 4 | 3 | 4 | 6 | 13 |