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Table 6 Scores for assessment of quality for genetic studies the Newcastle Ottawa Scale

From: The potential role of the antioxidant and detoxification properties of glutathione in autism spectrum disorders: a systematic review and meta-analysis

  Bowers et al. 2011 Ming et al. 2010 Buyske et al. 2006 James et al. 2006 Rose et al. 2006 Serajee 2004 Max Score
1 Selection        
Case definition 2 2 1 1 1 2 2
Representativeness 0 0 0 0 0 0 1
Selection of controls trios trios trios 0 0 trios 2
Definition of controls n/a n/a n/a 0 0 n/a 2
2 Comparability        
Control for confounding n/a n/a n/a 0 0 n/a n/a
3 Exposure        
Ascertainment 0 0 0 0 0 0 1
Method same cases/controls 1 1 1 1 1 1 1
4 Genetics        
HW equilibrium 1 0 1 1 1 1 1
Power calculations n/a 0 1 0 0 1 1
Control multiple comparisons 0 0 0 0 1 1 1
Population stratification n/a n/a 0 0 0 n/a 1
Overall score 4 3 4 3 4 6 13