From: Exploring metabolic dysfunction in chronic kidney disease
Hormonal, inflammatory or nutritional mediator | Effects of mediator on kidney function in normal state | Altered during CKD (levels/activities) | Potential or probable effects of alterations in mediators in human CKD on the following; | |||||
---|---|---|---|---|---|---|---|---|
W/CX | AX | IR | HYP | DYSL | CVDR&M | |||
Proinflammatory Cytokines | ↓ | ↑ | ↑ | ↑ | ↑ | ↑? | ↑ | ↑ |
GH-IGF-1 | ↑ | ↓ | ↑ | ? | ↑ | ? | ↑? | ↑? |
Angiotensin II | ↑ | ↑ | ↑? | ? | ↑ | ↑ | ? | ↑ |
Aldosterone | ↑ | ↑ | ↑? | ? | ↑ | ↑ | ? | ↑ |
Leptin | ? | ↑ | ↑? | ↑ | ↑ | ↑? | ↑ | ↑ |
Adiponectin | ↑? | ↑? | ? | ? | ↓↑? | ? | ↑? | ↑? |
Ghrelin | ? | ↑↓? | ↑? | ↑? | ? | ? | ? | ? |
Vitamin D | ↑ | ↓ | ↑? | ? | ↑? | ↑? | ↑? | ↑ |
Glucocorticoids | ↑ short-term ↓chronic | ↑? | ↑ | ↑? | ↑ | ↑ | ↑ | ↑ |