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Table 4 Insulin secretion capacity during hyperglycemic clamp

From: Meju, unsalted soybeans fermented with Bacillus subtilis and Aspergilus oryzae, potentiates insulinotropic actions and improves hepatic insulin sensitivity in diabetic rats

 

Control (n = 10)

CSB (n = 10)

MMS (n = 10)

TMS (n = 10)

Sham rats (n = 10)

Serum insulin at basal

state (ng/mL)

0.51 ± 0.09b

0.57 ± 0.09ab

0.67 ± 0.10a

0.64 ± 0.11a

0.79 ± 0.11

AUC of serum insulin

at first phase

5.3 ± 0.8c

4.3 ± 0.7d

7.3 ± 1.1a

6.5 ± 1.2b

13.5 ± 1.8

AUC of serum insulin

at second phase

47.2 ± 6.7b

42.1 ± 6.4b

65.1 ± 9.4a

60.4 ± 8.6a

114.5 ± 16.5

Glucose infusion rate (mg/kg bw/min)

7.5 ± 1.0b

7.4 ± 1·1b

10.1 ± 1.3a

9.4 ± 1.2a

16.1 ± 2.2

Insulin sensitivity (μmol glucose · min-1 · 100 g-1 per μmol insulin/L)

25.5 ± 3.4b

29·3 ± 3.9a

24.2 ± 2.9b

24.2 ± 3·4b

16.8 ± 2.3

  1. Values are mean ± SD. The control group was fed a casein diet, CSB group fed a cooked soybean diet, MMK group fed a diet containing 10% meju made with standard method, and TMK group fed a diet containing 10% meju made with traditional method. AUC of first phase insulin secretion was defined as the area under the curve (AUC) of serum insulin levels from 2 to 10 mins, with second phase from 60 to 120 mins. Insulin sensitivity at hyperglycemic state was calculated as the ratio of glucose infusion rate to steady-state plasma insulin levels.
  2. a,b Means of the same row without a common letter significantly differ at P < 0.05 by Tukey test.
  3. Significantly different from Px control at P < 0.05.