Body weight gain and voluntary running of the mice during the 19-week experiment. (A) After only 1 week, the body weight of low fat (LF) and high fat (HF) mice differed significantly (asterisk). After 7 weeks, the LFsed mice were significantly heavier than the LFexe mice (#). n = 14-15 animals/group. * P < 0.001, # P < 0.05. (B) Voluntary running distances per week on the running wheel during the 19-week intervention. After 9 weeks and after 12 weeks until the end of the experiment, the running distances differed significantly between the two diet groups. n = 14-15 animals/group. * P < 0.05 was considered significant. Results are means (±SD).