Effects of high-fat diet and physical activity on pyruvate dehydrogenase kinase-4 in mouse skeletal muscle

Nutrition & Metabolism

Table 2 Blood profiles of the mice after the 19-week experiment

Basic data	Low-fat diet		High-fat diet		ANOVAP-value
Basic data	Sedentary (n=14)	Running (n=15)	Sedentary (n=14)	Running (n=15)	Diet	Running	Diet*Running
Total cholesterol (mmol/l)^#	2.99 ± 0.88	2.70 ± 0.36	4.90 ± 0.54^***	4.52 ± 0.49^***,¤¤¤	<0.001	0.033	0.795
Triglycerides (mmol/l)	0.97 ± 0.23	1.05 ± 0.21	1.00 ± 0.24	0.90 ± 0.13^¤	0.274	0.807	0.089
Free fatty acids (mmol/l)	0.82 ± 0.15	0.92 ± 0.16	0.49 ± 0.13^***	0.44 ± 0.12^***,¤¤¤	<0.001	0.572	0.108
Fasting glucose (mmol/l)	8.92 ± 1.17	8.45 ± 0.90	9.39 ± 1.12	10.53 ± 0.72^{***,§§,¤¤¤}	<0.001	0.201	0.003
Fasting insulin (ng/ml)^#	0.43 ± 0.24	0.27 ± 0.16^*	2.25 ± 1.11^***	2.14 ± 0.82^***,¤¤¤	<0.001	0.125	0.112

^#Logarithmic transformation for normality and comparison.
Fasting blood glucose and insulin were measured after 18 weeks. * = vs. LFsed(P < 0.05), *** = vs. LFsed (P < 0.001), §§ = vs. HFsed (P < 0.01), ¤ = vs. LFexe (P < 0.05), ¤¤¤ = LFexe (P < 0.001). Results are means (±SD).

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