Cp < 0.05 compared with Control receiving the same treatment.
*p < 0.05 compared to the untreated state within the same group.
i interaction between SGA and rosiglitazone.
A) The Σmn representing the average fraction of 13 C atoms/molecule for the C2-4 fragment and C2-5 fragments are shown for cultures with and without rosiglitazone treatment. The data are presented as fractions of enrichment ± the SEM. Enrichment increased with rosiglitazone treatment in both Controls and SGA, while SGA maintained higher levels than Controls regardless of treatment. B) The PC and PDH pathway contributions are represented based on glutamate fragment enrichments. These data are presented as the median with the 25-75% interquartile ranges. At baseline, SGA demonstrated a lower PC/PDH ratio than Controls. With rosiglitazone, Controls decreased the PC/PDH ratio, while SGA increased it.