Skip to main content

Table 2 Baseline values and % change at 10 wks of intervention for fasting uric acid levels, mean 24-h uric acid exposure, fasting plasma RBP-4 concentrations, and fasting GGT, ALT and AST activities 1

From: Consumption of fructose- but not glucose-sweetened beverages for 10 weeks increases circulating concentrations of uric acid, retinol binding protein-4, and gamma-glutamyl transferase activity in overweight/obese humans

  Fructose Baseline Fructose 10 wks Fructose % change Glucose Baseline Gluctose 10 wks Glucose % change P-value for effect of sugar
24-h Uric Acid Exposure (mg/dL) 5.64 ± 0.14 6.05 ± 0.16 7.2 ± 1.1*** 5.67 ± 0.18 5.74 ± 0.18 1.3 ± 1.1 < 0.0001
Fasting Uric Acid (mg/dL) 5.70 ± 0.11 6.40 ± 0.13 11.9 ± 0.6*** 5.42 ± 0.16 5.65 ± 0.18 4.3 ± 1.5* 0.002
2 RBP-4 (ug/mL) 23.0 ± 1.1 25.2 ± 1.5 9.9 ± 4.1* 28.2 ± 1.4 24.5 ± 1.3 −12.5 ± 3.0** < 0.0001
3 GGT (U/L) 23.0 ± 4.1 26.7 ± 4.4 17.7 ± 5.2* 40.2 ± 9.6 33.8 ± 7.6 −10.7 ± 4.0*** < 0.0001
AST (U/L) 17.3 ± 1.6 16.1 ± 1.2 −3.7 ± 4.9 22.3 ± 2.3 17.8 ± 1.0 −13.1 ± 6.2** 0.08
ALT (U/L) 14.5 ± 1.6 13.7 ± 1.8 −5.2 ± 4.4 20.6 ± 3.2 13.7 ± 1.2 −22.3 ± 6.7 ** 0.04
  1. 1Values are means ± SEM, n = 31 (fructose n = 16; glucose n = 15) for all measurements except 24-h uric acid exposure (n = 30, fructose n = 16, glucose n = 14). PROC MIXED 3-factor (sugar, gender, and presence of metabolic syndrome) ANOVA; 2sugar × gender: P =0.037; 3effect of metabolic syndrome: P = 0.002, sugar × metabolic syndrome: P = 0.002.
  2. *P < 0.05, **P < 0.01, ***P < 0.001 for changes significantly different from zero.