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Table 2 Baseline values and % change at 10 wks of intervention for fasting uric acid levels, mean 24-h uric acid exposure, fasting plasma RBP-4 concentrations, and fasting GGT, ALT and AST activities 1

From: Consumption of fructose- but not glucose-sweetened beverages for 10 weeks increases circulating concentrations of uric acid, retinol binding protein-4, and gamma-glutamyl transferase activity in overweight/obese humans

 

Fructose Baseline

Fructose 10 wks

Fructose % change

Glucose Baseline

Gluctose 10 wks

Glucose % change

P-value for effect of sugar

24-h Uric Acid Exposure (mg/dL)

5.64 ± 0.14

6.05 ± 0.16

7.2 ± 1.1***

5.67 ± 0.18

5.74 ± 0.18

1.3 ± 1.1

< 0.0001

Fasting Uric Acid (mg/dL)

5.70 ± 0.11

6.40 ± 0.13

11.9 ± 0.6***

5.42 ± 0.16

5.65 ± 0.18

4.3 ± 1.5*

0.002

2 RBP-4 (ug/mL)

23.0 ± 1.1

25.2 ± 1.5

9.9 ± 4.1*

28.2 ± 1.4

24.5 ± 1.3

−12.5 ± 3.0**

< 0.0001

3 GGT (U/L)

23.0 ± 4.1

26.7 ± 4.4

17.7 ± 5.2*

40.2 ± 9.6

33.8 ± 7.6

−10.7 ± 4.0***

< 0.0001

AST (U/L)

17.3 ± 1.6

16.1 ± 1.2

−3.7 ± 4.9

22.3 ± 2.3

17.8 ± 1.0

−13.1 ± 6.2**

0.08

ALT (U/L)

14.5 ± 1.6

13.7 ± 1.8

−5.2 ± 4.4

20.6 ± 3.2

13.7 ± 1.2

−22.3 ± 6.7 **

0.04

  1. 1Values are means ± SEM, n = 31 (fructose n = 16; glucose n = 15) for all measurements except 24-h uric acid exposure (n = 30, fructose n = 16, glucose n = 14). PROC MIXED 3-factor (sugar, gender, and presence of metabolic syndrome) ANOVA; 2sugar × gender: P =0.037; 3effect of metabolic syndrome: P = 0.002, sugar × metabolic syndrome: P = 0.002.
  2. *P < 0.05, **P < 0.01, ***P < 0.001 for changes significantly different from zero.