Average weight as a function of time on the indicated diet. Body weight and calorie intake (Inset) in male C57Bl/6 mice during 16-week trial period from diet groups: Chow group (green), Zero-CHO group (red). Values are mean ± standard error. The blue dashed line shows body weights of the mice on a ketogenic diet (% energy ratio of CHO:fat:protein = 0:95:5) in the experiment reported by Kennedy that gained less weight than chow-fed mice and whose body weights were similar to calorie restricted (CR) mice that had consumed 65 % of their average chow intake . Statistical differences among the means were determined by one-way ANOVA for calorie intake (P = 0.38) and two-way ANOVA for body weight (P< 0.0001).