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Figure 2 | Nutrition & Metabolism

Figure 2

From: Mechanisms involved in cellular ceramide homeostasis

Figure 2

Hypothesized mechanisms controlling ceramide levels in various subcellular organelles: 1. Control of ceramide levels in the endoplasmic reticulum involves (a) de novo synthesis (a) and CERT mediated transfer to Golgi (b). 2. Regulation of ceramide levels in the Golgi compartment may involve (a) conversion to other sphingolipids such as sphingomyelin and glucosylceramides, and (b) incorporation into apoB-containing lipoproteins for secretion. 3. Maintenance of ceramide levels in the plasma membrane (PM) consists of (a) conversion to sphingomyelin, (b) delivery to lysosomes, and (c) efflux to plasma lipoproteins.

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