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Table 1 Levels of various sphingolipids in wildtype and SMS knockout mice

From: Mechanisms involved in cellular ceramide homeostasis

 

SM

PC

Cer

GluCer

GM3

Plasma

nmol/ml

  

ng/ml

 

Wildtype

105 ± 5

1443 ± 109

805 ± 33

3714 ± 358

342 ± 22

Sms1 KO

52 ± 3*

1322 ± 99

888 ± 80

25705 ± 2317*

1996 ± 219*

Wildtype

95 ± 3

1301 ± 78

796 ± 55

3209 ± 277

329 ± 34

Sms2 KO

47 ± 3*

1232 ± 102

1032 ± 50*

3638 ± 421

367 ± 51

Liver

nmol/mg protein

  

ng/mg protein

 

Wildtype

11 ± 2

102 ± 38

247 ± 29

104 ± 10

22 ± 2

Sms1 KO

7 ± 1*

108 ± 21

184 ± 21*

396 ± 31*

120 ± 13*

Wildtype

     

Sms2 KO

8 ± 1*

130 ± 15

284 + 42

109 ± 19

19 ± 5

Macrophages

     

Wildtype

63 ± 7

117 ± 22

985 ± 98

85 ± 17

151 ± 50

Sms1 KO

19 ± 5*

131 ± 19

1027 ± 128

1019 ± 26*

1255 ± 77*

Wildtype

61 ± 6

157 ± 33

890 ± 109

111 ± 20

103 ± 12

Sms2 KO

51 ± 2*

139 ± 23

962 ± 91

130 ± 18

99 ± 7

  1. Different sphingolipids were quantified by LC/MS/MS from tissues obtained from wildtype and SMS1 and SMS2 knockout mice. Statistical significance was evaluated using Student t-test. Values are mean ± SD, n = 6. *P<0.01. SM, sphingomyelin; PC, phosphatidylcholine; Cer, ceramide; DHCer, dihydroceramide; Glucer, glucosylceramide; Sph, sphingosine; S1P, sphingosine-1-phosphate; Sa1P, sphinganine-1-phosphate; GM3, ganglioside GM3. Data are modified from [25].