Figure 3

Aberrations of PI3K-Akt-mTORC1 signaling pathway in prostate cancer. Mutation-induced hyperactivated PI3K, Akt and overexpression of Rheb stimulate mTORC1. Loss of PTEN results in hyperactive Akt signaling. Androgens activate Akt via mTORC2 and via upregulation of L-type amino acid transporters (LAT) promote leucine-stimulated mTORC1 activation.