Effect of theophylline (50 mg/kg bw) on body weight change, food intake and tumour content in rats bearing the Yoshida AH-130 ascites hepatoma. Results are mean ± SEM. Body weight change is expressed as the difference between final body weight and initial body weight (IBW). Food intake is expressed in g/100 g IBW and refers to the food ingested during the period of the experiment prior to sacrifice, which took place 7 days after tumour inoculation. Tumour cell content is expressed in millions of cells. C = non-tumour-bearing rats, T = tumour-bearing rats, T + TPH = tumour-bearing rats treated with theophylline. Values that are significantly different by two-way analysis of variance (ANOVA) are indicated by: ### p < 0.001 (tumour effect).