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Table 3 Effects of theophylline (50 mg/kg bw) on heart parameters in rats bearing the Yoshida AH-130 ascites hepatoma

From: Theophylline is able to partially revert cachexia in tumour-bearing rats

   Experimental group    
  C(n = 5) T(n = 8) T + TPH(n = 9) ANOVA
     A B
LV ejection fraction (%) 77 ± 2 73 ± 2 72 ± 3 ns ns
Fractional shortening (%) 26 ± 6 23 ± 1 20 ± 3 ns ns
LVD dia (mm) 12 ± 0.1 2 ± 0.3 11 ± 0.2 ns ns
LVD sys (mm) 9 ± 0.7 9 ± 0.2 10 ± 0.4 ns ns
PWT dia (mm) 2.6 ± 0.1 2.4 ± 0.1 3 ± 0.1 ns 0,012
PWT sys (mm) 4 ± 0.2 3.2 ± 0.2 3.3 ± 0.2 0.05 ns
LV Vol dia (μl) 217 ± 22 220 ± 14 190 ± 17 ns ns
LV Vol sys (μl) 50 ± 8 55 ± 4 48 ± 7 ns ns
LVSV (μl) 167 ± 15 159 ± 10 139 ± 14 ns ns
LVmass (mg) 313 ± 6 274 ± 10 322 ± 14 0,032 0,005
  1. Echocardiographic data of non-tumour bearing rats (C), tumour bearing rats (T) and tumour bearing rats treated with theophylline (T + TPH). Results are mean ± SEM. LV ejection fraction: (LV vol dia-LV vol sys)/LV vol dia; fractional shortening: (LVD dia-LVD sys)/LVD sys; Left ventricle diameter in diastole: LVD dia; Left ventricle diameter in systole: LVD sys; posterior wall thickness in diastole: PWT dia; posterior wall thickness in systole: PWT sys; left ventricle volume in diastole: LV Vol dia; left ventricle volume in systole: LV Vol sys; left ventricle stroke volume: LVSV (LV Vol dia- LV Vol sys); left ventricle mass: LV mass (expressed as mg/100 g of initial body weight). Statistical significance of the results by two-way analysis of variance (ANOVA); ns: non-significant differences. A (tumour effect); B (treatment effect).