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Table 3 Effects of theophylline (50 mg/kg bw) on heart parameters in rats bearing the Yoshida AH-130 ascites hepatoma

From: Theophylline is able to partially revert cachexia in tumour-bearing rats

  

Experimental group

   
 

C(n = 5)

T(n = 8)

T + TPH(n = 9)

ANOVA

    

A

B

LV ejection fraction (%)

77 ± 2

73 ± 2

72 ± 3

ns

ns

Fractional shortening (%)

26 ± 6

23 ± 1

20 ± 3

ns

ns

LVD dia (mm)

12 ± 0.1

2 ± 0.3

11 ± 0.2

ns

ns

LVD sys (mm)

9 ± 0.7

9 ± 0.2

10 ± 0.4

ns

ns

PWT dia (mm)

2.6 ± 0.1

2.4 ± 0.1

3 ± 0.1

ns

0,012

PWT sys (mm)

4 ± 0.2

3.2 ± 0.2

3.3 ± 0.2

0.05

ns

LV Vol dia (μl)

217 ± 22

220 ± 14

190 ± 17

ns

ns

LV Vol sys (μl)

50 ± 8

55 ± 4

48 ± 7

ns

ns

LVSV (μl)

167 ± 15

159 ± 10

139 ± 14

ns

ns

LVmass (mg)

313 ± 6

274 ± 10

322 ± 14

0,032

0,005

  1. Echocardiographic data of non-tumour bearing rats (C), tumour bearing rats (T) and tumour bearing rats treated with theophylline (T + TPH). Results are mean ± SEM. LV ejection fraction: (LV vol dia-LV vol sys)/LV vol dia; fractional shortening: (LVD dia-LVD sys)/LVD sys; Left ventricle diameter in diastole: LVD dia; Left ventricle diameter in systole: LVD sys; posterior wall thickness in diastole: PWT dia; posterior wall thickness in systole: PWT sys; left ventricle volume in diastole: LV Vol dia; left ventricle volume in systole: LV Vol sys; left ventricle stroke volume: LVSV (LV Vol dia- LV Vol sys); left ventricle mass: LV mass (expressed as mg/100 g of initial body weight). Statistical significance of the results by two-way analysis of variance (ANOVA); ns: non-significant differences. A (tumour effect); B (treatment effect).