TY - JOUR AU - Stipanuk, M. H. PY - 2007 DA - 2007// TI - Leucine and protein synthesis: mTOR and beyond JO - Nutr Rev VL - 65 UR - https://doi.org/10.1111/j.1753-4887.2007.tb00289.x DO - 10.1111/j.1753-4887.2007.tb00289.x ID - Stipanuk2007 ER - TY - JOUR AU - Zanchi, N. E. AU - Nicastro, H. AU - Lancha, A. H. PY - 2008 DA - 2008// TI - Potential antiproteolytic effects of L-leucine: observations of in vitro and in vivo studies JO - Nutr Metab (Lond) VL - 5 UR - https://doi.org/10.1186/1743-7075-5-20 DO - 10.1186/1743-7075-5-20 ID - Zanchi2008 ER - TY - JOUR AU - Lynch, C. J. AU - Patson, B. J. AU - Anthony, J. AU - Vaval, A. AU - Jefferson, L. S. AU - Vary, T. C. PY - 2002 DA - 2002// TI - Leucine is a direct-acting nutrient signal that regulates protein synthesis in adipose tissue JO - Am J Physiol Endocrinol Metab VL - 283 UR - https://doi.org/10.1152/ajpendo.00084.2002 DO - 10.1152/ajpendo.00084.2002 ID - Lynch2002 ER - TY - JOUR AU - Sun, X. AU - Zemel, M. PY - 2007 DA - 2007// TI - Leucine and calcium regulate fat metabolism and energy partitioning in murine adipocytes and muscle cells JO - Lipids VL - 42 UR - https://doi.org/10.1007/s11745-007-3029-5 DO - 10.1007/s11745-007-3029-5 ID - Sun2007 ER - TY - JOUR AU - Sun, X. AU - Zemel, M. B. PY - 2009 DA - 2009// TI - Leucine modulation of mitochondrial mass and oxygen consumption in skeletal muscle cells and adipocytes JO - Nutr Metab (Lond) VL - 6 UR - https://doi.org/10.1186/1743-7075-6-26 DO - 10.1186/1743-7075-6-26 ID - Sun2009 ER - TY - JOUR AU - Donato, J. AU - Pedrosa, R. G. AU - Cruzat, V. F. AU - Pires, I. S. AU - Tirapegui, J. PY - 2006 DA - 2006// TI - Effects of leucine supplementation on the body composition and protein status of rats submitted to food restriction JO - Nutrition VL - 22 UR - https://doi.org/10.1016/j.nut.2005.12.008 DO - 10.1016/j.nut.2005.12.008 ID - Donato2006 ER - TY - JOUR AU - Zhang, Y. AU - Guo, K. AU - LeBlanc, R. E. AU - Loh, D. AU - Schwartz, G. J. AU - Yu, Y. H. PY - 2007 DA - 2007// TI - Increasing dietary leucine intake reduces diet-induced obesity and improves glucose and cholesterol metabolism in mice via multimechanisms JO - Diabetes VL - 56 UR - https://doi.org/10.2337/db07-0123 DO - 10.2337/db07-0123 ID - Zhang2007 ER - TY - JOUR AU - Bruckbauer, A. AU - Zemel, M. B. PY - 2011 DA - 2011// TI - Effects of dairy consumption on SIRT1 and mitochondrial biogenesis in adipocytes and muscle cells JO - Nutr Metab (Lond) VL - 8 UR - https://doi.org/10.1186/1743-7075-8-91 DO - 10.1186/1743-7075-8-91 ID - Bruckbauer2011 ER - TY - JOUR AU - Bruckbauer, A. AU - Gouffon, J. AU - Rekapalli, B. AU - Zemel, M. B. PY - 2009 DA - 2009// TI - The effects of dairy components on energy partitioning and metabolic risk in mice: a microarray study JO - J Nutrigenet Nutrigenomics VL - 2 UR - https://doi.org/10.1159/000205936 DO - 10.1159/000205936 ID - Bruckbauer2009 ER - TY - JOUR AU - Haigis, M. C. AU - Guarente, L. P. PY - 2006 DA - 2006// TI - Mammalian sirtuins–emerging roles in physiology, aging, and calorie restriction JO - Genes Dev VL - 20 UR - https://doi.org/10.1101/gad.1467506 DO - 10.1101/gad.1467506 ID - Haigis2006 ER - TY - JOUR AU - Verdin, E. AU - Hirschey, M. D. AU - Finley, L. W. AU - Haigis, M. C. PY - 2010 DA - 2010// TI - Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling JO - Trends Biochem Sci VL - 35 UR - https://doi.org/10.1016/j.tibs.2010.07.003 DO - 10.1016/j.tibs.2010.07.003 ID - Verdin2010 ER - TY - JOUR AU - Carafa, V. AU - Nebbioso, A. AU - Altucci, L. PY - 2012 DA - 2012// TI - Sirtuins and disease: the road ahead JO - Front Pharmacol VL - 3 UR - https://doi.org/10.3389/fphar.2012.00004 DO - 10.3389/fphar.2012.00004 ID - Carafa2012 ER - TY - JOUR AU - Yeung, F. AU - Hoberg, J. E. AU - Ramsey, C. S. AU - Keller, M. D. AU - Jones, D. R. AU - Frye, R. A. AU - Mayo, M. W. PY - 2004 DA - 2004// TI - Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase JO - EMBO J VL - 23 UR - https://doi.org/10.1038/sj.emboj.7600244 DO - 10.1038/sj.emboj.7600244 ID - Yeung2004 ER - TY - JOUR AU - Nemoto, S. AU - Fergusson, M. M. AU - Finkel, T. PY - 2005 DA - 2005// TI - SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha} JO - J Biol Chem VL - 280 UR - https://doi.org/10.1074/jbc.M501485200 DO - 10.1074/jbc.M501485200 ID - Nemoto2005 ER - TY - JOUR AU - Martinez-Pastor, B. AU - Mostoslavsky, R. PY - 2012 DA - 2012// TI - Sirtuins, metabolism, and cancer JO - Front Pharmacol VL - 3 UR - https://doi.org/10.3389/fphar.2012.00022 DO - 10.3389/fphar.2012.00022 ID - Martinez-Pastor2012 ER - TY - JOUR AU - Sun, C. AU - Zhang, F. AU - Ge, X. AU - Yan, T. AU - Chen, X. AU - Shi, X. AU - Zhai, Q. PY - 2007 DA - 2007// TI - SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B JO - Cell Metab VL - 6 UR - https://doi.org/10.1016/j.cmet.2007.08.014 DO - 10.1016/j.cmet.2007.08.014 ID - Sun2007 ER - TY - JOUR AU - Baur, J. A. AU - Pearson, K. J. AU - Price, N. L. AU - Jamieson, H. A. AU - Lerin, C. AU - Kalra, A. AU - Prabhu, V. V. AU - Allard, J. S. AU - Lopez-Lluch, G. AU - Lewis, K. PY - 2006 DA - 2006// TI - Resveratrol improves health and survival of mice on a high-calorie diet JO - Nature VL - 444 UR - https://doi.org/10.1038/nature05354 DO - 10.1038/nature05354 ID - Baur2006 ER - TY - JOUR AU - Lagouge, M. AU - Argmann, C. AU - Gerhart-Hines, Z. AU - Meziane, H. AU - Lerin, C. AU - Daussin, F. AU - Messadeq, N. AU - Milne, J. AU - Lambert, P. AU - Elliott, P. PY - 2006 DA - 2006// TI - Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha JO - Cell VL - 127 UR - https://doi.org/10.1016/j.cell.2006.11.013 DO - 10.1016/j.cell.2006.11.013 ID - Lagouge2006 ER - TY - JOUR AU - Park, S. J. AU - Ahmad, F. AU - Philp, A. AU - Baar, K. AU - Williams, T. AU - Luo, H. AU - Ke, H. AU - Rehmann, H. AU - Taussig, R. AU - Brown, A. L. PY - 2012 DA - 2012// TI - Resveratrol ameliorates aging-related metabolic phenotypes by inhibiting cAMP phosphodiesterases JO - Cell VL - 148 UR - https://doi.org/10.1016/j.cell.2012.01.017 DO - 10.1016/j.cell.2012.01.017 ID - Park2012 ER - TY - JOUR AU - Price, N. L. AU - Gomes, A. P. AU - Ling, A. J. AU - Duarte, F. V. AU - Martin-Montalvo, A. AU - North, B. J. AU - Agarwal, B. AU - Ye, L. AU - Ramadori, G. AU - Teodoro, J. S. PY - 2012 DA - 2012// TI - SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function JO - Cell Metab VL - 15 UR - https://doi.org/10.1016/j.cmet.2012.04.003 DO - 10.1016/j.cmet.2012.04.003 ID - Price2012 ER - TY - JOUR AU - Baur, J. A. AU - Sinclair, D. A. PY - 2006 DA - 2006// TI - Therapeutic potential of resveratrol: the in vivo evidence JO - Nat Rev Drug Discov VL - 5 UR - https://doi.org/10.1038/nrd2060 DO - 10.1038/nrd2060 ID - Baur2006 ER - TY - CHAP AU - Crandall, J. P. AU - Oram, V. AU - Trandafirescu, G. AU - Reid, M. AU - Kishore, P. AU - Hawkins, M. AU - Cohen, H. W. AU - Barzilai, N. PY - 2012 DA - 2012// TI - Pilot Study of Resveratrol in Older Adults With Impaired Glucose Tolerance BT - J Gerontol A Biol Sci Med Sci ID - Crandall2012 ER - TY - JOUR AU - Mukherjee, S. AU - Dudley, J. I. AU - Das, D. K. PY - 2010 DA - 2010// TI - Dose-dependency of resveratrol in providing health benefits JO - Dose–response VL - 8 ID - Mukherjee2010 ER - TY - JOUR AU - Timmer, S. AU - Auwerx, J. AU - Schrauwen, P. PY - 2012 DA - 2012// TI - The journey of resveratrol from yeast to human JO - Aging (Albany NY) VL - 4 ID - Timmer2012 ER - TY - JOUR AU - Smoliga, J. M. AU - Vang, O. AU - Baur, J. A. PY - 2011 DA - 2011// TI - Challenges of translating basic research into therapeutics: resveratrol as an example JO - J Gerontol A Biol Sci Med Sci VL - 67 ID - Smoliga2011 ER - TY - JOUR AU - Smoliga, J. M. AU - Baur, J. A. AU - Hausenblas, H. A. PY - 2011 DA - 2011// TI - Resveratrol and health–a comprehensive review of human clinical trials JO - Mol Nutr Food Res VL - 55 UR - https://doi.org/10.1002/mnfr.201100143 DO - 10.1002/mnfr.201100143 ID - Smoliga2011 ER - TY - JOUR AU - Boocock, D. J. AU - Faust, G. E. AU - Patel, K. R. AU - Schinas, A. M. AU - Brown, V. A. AU - Ducharme, M. P. AU - Booth, T. D. AU - Crowell, J. A. AU - Perloff, M. AU - Gescher, A. J. PY - 2007 DA - 2007// TI - Phase I dose escalation pharmacokinetic study in healthy volunteers of resveratrol, a potential cancer chemopreventive agent JO - Cancer Epidemiol Biomarkers Prev VL - 16 UR - https://doi.org/10.1158/1055-9965.EPI-07-0022 DO - 10.1158/1055-9965.EPI-07-0022 ID - Boocock2007 ER - TY - JOUR AU - Brand, H. S. AU - Jorning, G. G. AU - Chamuleau, R. A. AU - Abraham-Inpijn, L. PY - 1997 DA - 1997// TI - Effect of a protein-rich meal on urinary and salivary free amino acid concentrations in human subjects JO - Clin Chim Acta VL - 264 UR - https://doi.org/10.1016/S0009-8981(97)00070-3 DO - 10.1016/S0009-8981(97)00070-3 ID - Brand1997 ER - TY - JOUR AU - Almeida, L. AU - Vaz-da-Silva, M. AU - Falcao, A. AU - Soares, E. AU - Costa, R. AU - Loureiro, A. I. AU - Fernandes-Lopes, C. AU - Rocha, J. F. AU - Nunes, T. AU - Wright, L. PY - 2009 DA - 2009// TI - Pharmacokinetic and safety profile of trans-resveratrol in a rising multiple-dose study in healthy volunteers JO - Mol Nutr Food Res VL - 53 UR - https://doi.org/10.1002/mnfr.200800177 DO - 10.1002/mnfr.200800177 ID - Almeida2009 ER - TY - JOUR AU - Barger, J. L. AU - Kayo, T. AU - Vann, J. M. AU - Arias, E. B. AU - Wang, J. AU - Hacker, T. A. AU - Wang, Y. AU - Raederstorff, D. AU - Morrow, J. D. AU - Leeuwenburgh, C. PY - 2008 DA - 2008// TI - A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice JO - PLoS One VL - 3 UR - https://doi.org/10.1371/journal.pone.0002264 DO - 10.1371/journal.pone.0002264 ID - Barger2008 ER - TY - JOUR AU - Nin, V. AU - Escande, C. AU - Chini, C. C. AU - Giri, S. AU - Camacho-Pereira, J. AU - Matalonga, J. AU - Lou, Z. AU - Chini, E. N. PY - 2012 DA - 2012// TI - Role of Deleted in Breast Cancer 1 (DBC1) Protein in SIRT1 Deacetylase Activation Induced by Protein Kinase A and AMP-activated Protein Kinase JO - J Biol Chem VL - 287 UR - https://doi.org/10.1074/jbc.M112.365874 DO - 10.1074/jbc.M112.365874 ID - Nin2012 ER - TY - JOUR AU - Taylor, M. AU - Wallhaus, T. R. AU - Degrado, T. R. AU - Russell, D. C. AU - Stanko, P. AU - Nickles, R. J. AU - Stone, C. K. PY - 2001 DA - 2001// TI - An evaluation of myocardial fatty acid and glucose uptake using PET with [18 F]fluoro-6-thia-heptadecanoic acid and [18 F]FDG in Patients with Congestive Heart Failure JO - J Nucl Med VL - 42 ID - Taylor2001 ER - TY - JOUR AU - Guiducci, L. AU - Gronroos, T. AU - Jarvisalo, M. J. AU - Kiss, J. AU - Viljanen, A. AU - Naum, A. G. AU - Viljanen, T. AU - Savunen, T. AU - Knuuti, J. AU - Ferrannini, E. PY - 2007 DA - 2007// TI - Biodistribution of the fatty acid analogue 18 F-FTHA: plasma and tissue partitioning between lipid pools during fasting and hyperinsulinemia JO - J Nucl Med VL - 48 ID - Guiducci2007 ER - TY - CHAP AU - LeBlanc, A. K. AU - Akula, M. AU - Martin, E. B. AU - Rowe, J. A. AU - Galyon, G. D. AU - Moyers, T. D. AU - Stuckey, A. C. AU - Long, M. J. AU - Wall, J. S. AU - Kennel, S. J. PY - 2011 DA - 2011// TI - Whole-body distribution of 14(R,S)-[18F]fluoro-6-thia-heptadecanoic acid with Positron Emission Tomography/Computed Tomography (PET/CT) in domestic cats BT - World Molecular Imaging Congress PB - Poster Presentation with Abstract, CY - San Diego, CA ID - LeBlanc2011 ER - TY - JOUR AU - Sugawara, Y. AU - Zasadny, K. R. AU - Neuhoff, A. W. AU - Wahl, R. L. PY - 1999 DA - 1999// TI - Reevaluation of the standardized uptake value for FDG: variations with body weight and methods for correction JO - Radiology VL - 213 UR - https://doi.org/10.1148/radiology.213.2.r99nv37521 DO - 10.1148/radiology.213.2.r99nv37521 ID - Sugawara1999 ER - TY - JOUR AU - Rodgers, J. T. AU - Lerin, C. AU - Haas, W. AU - Gygi, S. P. AU - Spiegelman, B. M. AU - Puigserver, P. PY - 2005 DA - 2005// TI - Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1 JO - Nature VL - 434 UR - https://doi.org/10.1038/nature03354 DO - 10.1038/nature03354 ID - Rodgers2005 ER - TY - JOUR AU - Yu, J. AU - Auwerx, J. PY - 2009 DA - 2009// TI - The role of sirtuins in the control of metabolic homeostasis JO - Ann N Y Acad Sci VL - 1173 UR - https://doi.org/10.1111/j.1749-6632.2009.04952.x DO - 10.1111/j.1749-6632.2009.04952.x ID - Yu2009 ER - TY - JOUR AU - Yoshizaki, T. AU - Schenk, S. AU - Imamura, T. AU - Babendure, J. L. AU - Sonoda, N. AU - Bae, E. J. AU - Oh, D. Y. AU - Lu, M. AU - Milne, J. C. AU - Westphal, C. PY - 2010 DA - 2010// TI - SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity JO - Am J Physiol Endocrinol Metab VL - 298 UR - https://doi.org/10.1152/ajpendo.00417.2009 DO - 10.1152/ajpendo.00417.2009 ID - Yoshizaki2010 ER - TY - JOUR AU - Milne, J. C. AU - Lambert, P. D. AU - Schenk, S. AU - Carney, D. P. AU - Smith, J. J. AU - Gagne, D. J. AU - Jin, L. AU - Boss, O. AU - Perni, R. B. AU - Vu, C. B. PY - 2007 DA - 2007// TI - Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes JO - Nature VL - 450 UR - https://doi.org/10.1038/nature06261 DO - 10.1038/nature06261 ID - Milne2007 ER - TY - JOUR AU - Pearson, K. J. AU - Baur, J. A. AU - Lewis, K. N. AU - Peshkin, L. AU - Price, N. L. AU - Labinskyy, N. AU - Swindell, W. R. AU - Kamara, D. AU - Minor, R. K. AU - Perez, E. PY - 2008 DA - 2008// TI - Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span JO - Cell Metab VL - 8 UR - https://doi.org/10.1016/j.cmet.2008.06.011 DO - 10.1016/j.cmet.2008.06.011 ID - Pearson2008 ER - TY - JOUR AU - Kang, W. AU - Hong, H. J. AU - Guan, J. AU - Kim, D. G. AU - Yang, E. J. AU - Koh, G. AU - Park, D. AU - Han, C. H. AU - Lee, Y. J. AU - Lee, D. H. PY - 2012 DA - 2012// TI - Resveratrol improves insulin signaling in a tissue-specific manner under insulin-resistant conditions only: in vitro and in vivo experiments in rodents JO - Metabolism VL - 61 UR - https://doi.org/10.1016/j.metabol.2011.08.003 DO - 10.1016/j.metabol.2011.08.003 ID - Kang2012 ER - TY - JOUR AU - Robich, M. P. AU - Osipov, R. M. AU - Chu, L. M. AU - Han, Y. AU - Feng, J. AU - Nezafat, R. AU - Clements, R. T. AU - Manning, W. J. AU - Sellke, F. W. PY - 2011 DA - 2011// TI - Resveratrol modifies risk factors for coronary artery disease in swine with metabolic syndrome and myocardial ischemia JO - Eur J Pharmacol VL - 664 UR - https://doi.org/10.1016/j.ejphar.2011.04.059 DO - 10.1016/j.ejphar.2011.04.059 ID - Robich2011 ER - TY - JOUR AU - Brasnyo, P. AU - Molnar, G. A. AU - Mohas, M. AU - Marko, L. AU - Laczy, B. AU - Cseh, J. AU - Mikolas, E. AU - Szijarto, I. A. AU - Merei, A. AU - Halmai, R. PY - 2011 DA - 2011// TI - Resveratrol improves insulin sensitivity, reduces oxidative stress and activates the Akt pathway in type 2 diabetic patients JO - Br J Nutr VL - 106 UR - https://doi.org/10.1017/S0007114511000316 DO - 10.1017/S0007114511000316 ID - Brasnyo2011 ER - TY - JOUR AU - Calabrese, E. J. AU - Mattson, M. P. AU - Calabrese, V. PY - 2010 DA - 2010// TI - Resveratrol commonly displays hormesis: occurrence and biomedical significance JO - Hum Exp Toxicol VL - 29 UR - https://doi.org/10.1177/0960327110383625 DO - 10.1177/0960327110383625 ID - Calabrese2010 ER - TY - CHAP AU - Cho, S. J. AU - Jung, U. J. AU - Choi, M. S. PY - 2012 DA - 2012// TI - Differential effects of low-dose resveratrol on adiposity and hepatic steatosis in diet-induced obese mice BT - Br J Nutr ID - Cho2012 ER - TY - JOUR AU - Layman, D. K. AU - Walker, D. A. PY - 2006 DA - 2006// TI - Potential importance of leucine in treatment of obesity and the metabolic syndrome JO - J Nutr VL - 136 ID - Layman2006 ER - TY - JOUR AU - Layman, D. K. PY - 2003 DA - 2003// TI - The role of leucine in weight loss diets and glucose homeostasis JO - J Nutr VL - 133 ID - Layman2003 ER - TY - JOUR AU - Macotela, Y. AU - Emanuelli, B. AU - Bang, A. M. AU - Espinoza, D. O. AU - Boucher, J. AU - Beebe, K. AU - Gall, W. AU - Kahn, R. PY - 2011 DA - 2011// TI - Dietary Leucine - An Envrionmental Modifier of Insulin Resistance Acting on Multiple Levels of Metabolism JO - PLoS One VL - 6 UR - https://doi.org/10.1371/journal.pone.0021187 DO - 10.1371/journal.pone.0021187 ID - Macotela2011 ER - TY - JOUR AU - Guo, K. AU - Yu, Y. H. AU - Hou, J. AU - Zhang, Y. PY - 2010 DA - 2010// TI - Chronic leucine supplementation improves glycemic control in etiologically distinct mouse models of obesity and diabetes mellitus JO - Nutr Metab (Lond) VL - 7 UR - https://doi.org/10.1186/1743-7075-7-57 DO - 10.1186/1743-7075-7-57 ID - Guo2010 ER - TY - CHAP AU - Freudenberg, A. AU - Petzke, K. J. AU - Klaus, S. PY - 2012 DA - 2012// TI - Comparison of high-protein diets and leucine supplementation in the prevention of metabolic syndrome and related disorders in mice BT - J Nutr Biochem ID - Freudenberg2012 ER - TY - JOUR AU - Salminen, A. AU - Hyttinen, J. M. AU - Kaarniranta, K. PY - 2011 DA - 2011// TI - AMP-activated protein kinase inhibits NF-kappaB signaling and inflammation: impact on healthspan and lifespan JO - J Mol Med (Berl) VL - 89 UR - https://doi.org/10.1007/s00109-011-0748-0 DO - 10.1007/s00109-011-0748-0 ID - Salminen2011 ER - TY - JOUR AU - Canto, C. AU - Gerhart-Hines, Z. AU - Feige, J. N. AU - Lagouge, M. AU - Noriega, L. AU - Milne, J. C. AU - Elliott, P. J. AU - Puigserver, P. AU - Auwerx, J. PY - 2009 DA - 2009// TI - AMPK regulates energy expenditure by modulating NAD + metabolism and SIRT1 activity JO - Nature VL - 458 UR - https://doi.org/10.1038/nature07813 DO - 10.1038/nature07813 ID - Canto2009 ER - TY - JOUR AU - Yamauchi, T. AU - Kamon, J. AU - Minokoshi, Y. AU - Ito, Y. AU - Waki, H. AU - Uchida, S. AU - Yamashita, S. AU - Noda, M. AU - Kita, S. AU - Ueki, K. PY - 2002 DA - 2002// TI - Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase JO - Nat Med VL - 8 UR - https://doi.org/10.1038/nm788 DO - 10.1038/nm788 ID - Yamauchi2002 ER -