| |
Control
|
Low Resveratrol1
|
High Resveratrol2
|
Low HMB3
|
Low Resv/ Low HMB
|
Low Resv/ High HMB4
|
Low Resv/Leucine5
|
P value
|
|---|
|
Glucose (mM)
|
4.97 ± 0.60
|
5.14 ± 0.85
|
5.14 ± 0.75
|
4.28 ± 0.49
|
4.67 ± 0.49
|
4.33 ± 0.41
|
5.05 ± 0.92
|
NS
|
|
Insulin (μU/mL)
|
12.5 ± 3.4a
|
10.4 ± 1.6a
|
10.1 ± 2.7a
|
8.3 ± 1.1a
|
5.8 ± 0.7b
|
3.9 ± 1.2b
|
5.5 ± 1.4b
|
P < 0.005
|
|
HOMA
IR
|
2.61 ± 0.82a
|
2.41 ± 0.66a
|
0.59 ± 0.26b
|
1.93 ± 0.32a
|
1.18 ± 0.25c
|
0.87 ± 0.31b
|
1.14 ± 0.37c
|
P < 0.01
|
|
Muscle Glucose Uptake (
18
FDG SUV)
|
3.64 ± 0.88a
|
3.63 ± 1.29a
|
3.87 ± 0.32a
|
2.99 ± 0.42a
|
5.90 ± 0.41b
|
5.93 ± 1.63b
|
5.68 ± 0.75b
|
P < 0.02
|
- Mice were fed a high fat-diet with indicated treatments for 6 weeks. Muscle glucose uptake was determined via PET/CT. The homeostasis model assessment of insulin resistance (HOMAIR) was used as a screening index of changes in insulin sensitivity and was calculated via standard formula from fasting plasma insulin and glucose (HOMAIR = [Insulin (uU/mL) X glucose (mM)]/22.5). Data are presented as means ± SE (n = 5 to 10). Non-matching letter superscripts in each row denote significant differences at the indicated p value.
- 1Low resveratrol: 12.5 mg resveratrol/kg diet.
- 2High resveratrol: 225 mg resveratrol/kg diet.
- 3Low HMB: 2 g hyroxymethylbutyrate (calcium salt).
- 4High HMB: 10 g hyroxymethylbutyrate (calcium salt).
- 5Leucine: 24 g leucine/kg diet.
