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Table 2 Effects of resveratrol, leucine and HMB on indices of insulin sensitivity in diet-induced obese mice

From: Synergistic effects of leucine and resveratrol on insulin sensitivity and fat metabolism in adipocytes and mice

  Control Low Resveratrol1 High Resveratrol2 Low HMB3 Low Resv/ Low HMB Low Resv/ High HMB4 Low Resv/Leucine5 P value
Glucose (mM) 4.97 ± 0.60 5.14 ± 0.85 5.14 ± 0.75 4.28 ± 0.49 4.67 ± 0.49 4.33 ± 0.41 5.05 ± 0.92 NS
Insulin (μU/mL) 12.5 ± 3.4a 10.4 ± 1.6a 10.1 ± 2.7a 8.3 ± 1.1a 5.8 ± 0.7b 3.9 ± 1.2b 5.5 ± 1.4b P < 0.005
HOMA IR 2.61 ± 0.82a 2.41 ± 0.66a 0.59 ± 0.26b 1.93 ± 0.32a 1.18 ± 0.25c 0.87 ± 0.31b 1.14 ± 0.37c P < 0.01
Muscle Glucose Uptake ( 18 FDG SUV) 3.64 ± 0.88a 3.63 ± 1.29a 3.87 ± 0.32a 2.99 ± 0.42a 5.90 ± 0.41b 5.93 ± 1.63b 5.68 ± 0.75b P < 0.02
  1. Mice were fed a high fat-diet with indicated treatments for 6 weeks. Muscle glucose uptake was determined via PET/CT. The homeostasis model assessment of insulin resistance (HOMAIR) was used as a screening index of changes in insulin sensitivity and was calculated via standard formula from fasting plasma insulin and glucose (HOMAIR = [Insulin (uU/mL) X glucose (mM)]/22.5). Data are presented as means ± SE (n = 5 to 10). Non-matching letter superscripts in each row denote significant differences at the indicated p value.
  2. 1Low resveratrol: 12.5 mg resveratrol/kg diet.
  3. 2High resveratrol: 225 mg resveratrol/kg diet.
  4. 3Low HMB: 2 g hyroxymethylbutyrate (calcium salt).
  5. 4High HMB: 10 g hyroxymethylbutyrate (calcium salt).
  6. 5Leucine: 24 g leucine/kg diet.