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Table 1 Change (Δ) in fat free mass (FFM), fat mass and total body weight ± standard error of the mean in women from previous studies examining the effects of increased dietary protein intake and weight loss on body composition (Farnsworth et al. [[28]]; Luscombe-Marsh et al. [[65]]; Noakes et al. [[25]]; Layman et al. [[29]]; Piatti et al ., 1994 [[31]])

From: MTOR signaling and ubiquitin-proteosome gene expression in the preservation of fat free mass following high protein, calorie restricted weight loss

Author Population N (M/F) Intervention ΔFFM† ΔFat mass† ΔTotal body weight†
Farnsworth et al.[28] Healthy Obese 57 (14/43) HP Diet vs SP Diet (equal% energy from fat) 12 weeks energy restriction HP Diet −0.1 ± 0.3** HP Diet −6.6 ± 0.5 HP Diet −6.6 ± 0.5
4 weeks energy balance SP Diet −1.5 ± 0.3 SP Diet −7.1 ± 2.0 SP Diet −7.4 ± 0.5
Luscombe-Marsh et al.[65] Healthy Obese 57 (25/32) LF-HP Diet vs HF-SP Diet 12 weeks energy restriction LF-HP Diet −2.2 ± 0.5* LF/HP Diet −4.3 ± 0.8 LF-HP Diet −7.8 ± 0.8
4 weeks energy balance HF-SP Diet −3.1 ± 0.5 HF/SP Diet −4.8 ± 1.2 HF-SP Diet −7.9 ± 1.3
Layman et al.[29] Healthy Obese 25 F High protein vs High Carbohydrate (similar% energy from fat) HP Diet −0.88 ± 0.3** HP Diet-5.6 ± 0.5 HP Diet −7.53 ± 1.4
10 weeks energy restriction HC Diet −1.21 ± 0.6 HC Diet-4.7 ± 0.7 HC Diet −6.96 ± 1.36
Noakes et al.[25] Healthy Obese 100 F HP vs SP Diet (equal% energy from fat) HP Diet −1.5 ± 0.3 HP Diet −5.7 ± 0.6 HP Diet −7.6 ± 0.4
12 weeks energy restriction SP Diet −1.8 ± 0.3 SP Diet −4.5 ± 0.5 SP Diet −6.9 ± 0.5
Piatti et al.[31] Healthy Obese 25 F HP vs SP Diet (equal% energy from fat) HP Diet −1.40 ± 0.6** HP Diet −3.2 ± 0.6 HP Diet −4.5 ± 0.4
21 days energy restriction SP Diet −3.02 ± 0.6 SP Diet −3.3 ± 0.5 SP Diet −6.4 ± 0.9
  1. †Data from women only.
  2. **Indicates a significant retention of lean mass in the HP diet group and *indicates a trend.