Table 2 List of entities identified by GO and the pathways identified by KEGG of significantly up-regulated and down-regulated genes in liver tissues in 6- and 25-week-old CP
From: Altered gene and protein expression in liver of the obese spontaneously hypertensive/NDmcr-cp rat
GO accession | GO Term | Pvalue |
|---|---|---|
Up-regulation | Â | Â |
GO:0005489 | electron transporter activity | 7.31E-06 |
GO:0006118 | electron transport | 7.42E-06 |
GO:0006629 | lipid metabolism | 5.07E-05 |
Down-regulation | Â | Â |
GO:0005489 | electron transporter activity | 1.00E-03 |
GO:0006118 | electron transport | 1.01E-03 |
GO:0006811 | ion transport | 1.55E-03 |
GO:0010740 | transferase | 3.29E-03 |
GO:0005216 | ion channel activity | 4.86E-03 |
Predicted pathway | P value | |
Up-regulation | Â | Â |
Carbon fixation | 2.54E-06 | |
Pentose phosphate pathway | 1.86E-04 | |
Pyruvate metabolism | 4.07E-04 | |
Glutathione metabolism | 4.07E-04 | |
Fructose and mannose metabolism | 5.27E-04 | |
Metabolism of xenobiotics by cytochrome P450 | 7.61E-04 | |
Fatty acid metabolism | 9.78E-04 | |
Glycolysis-Gluconeogenesis | 1.04E-03 | |
Arachidonic acid metabolism | 1.49E-03 | |
Fatty acid biosynthesis | 5.44E-03 | |
Down-regulation | Â | |
gamma-hexachlorocyclohexane degradation | 6.48E-07 | |
Metabolism of xenobiotics by cytochrome P450 | 7.14E-06 | |
Linoleic acid metabolism | 2.36E-06 | |
PPARγ signaling pathway | 2.78E-03 | |
Methionine metabolism | 7.57E-03 | |
Glyoxylate and dicarboxylate metabolism | 7.57E-03 | |