Dietary resistant starch dose-dependently reduces adiposity in obesity-prone and obesity-resistant male rats

Nutrition & Metabolism

Table 4 Large intestinal tissue weights and fermentation parameters of obesity-prone and obesity-resistant rats consuming diets with different levels of resistant starch for 4 wk ¹

	Resistant starch, % of diet weight					Main Effects (P-value)
	0%	4%	8%	12%	16%	RS	Phenotype	RS x Phenotype
Caecum
Digesta weight, g								0.015
Obesity-prone	1.7 ± 0.2 ^a	2.3 ± 0.3 ^a	6.4 ± 1.0 ^b	6.9 ± 1.0 ^b	11.5 ± 1.6 ^c
Obesity-resistant	1.5 ± 0.1 ^a	2.5 ± 0.5 ^ab	6.0 ± 0.7 ^b	9.5 ± 0.9 ^c	7.4 ± 1.3 ^bc
Total SCFA pool, mmol	169 ± 11 ^a	288 ± 43 ^ab	657 ± 83 ^bc	985 ± 150 ^c	1029 ± 150 ^c	0.0001	ns	ns
Digesta pH	7.2 ± 0.1 ^c	6.8 ± 0.1 ^b	6.2 ± 0.1 ^a	6.0 ± 0.1 ^a	5.9 ± 0.1 ^a	0.0001	ns	ns
Colon
Digesta weight, g	1.0 ± 0.1 ^a	1.9 ± 0.1 ^b	2.1 ± 0.2 ^bc	3.0 ± 0.2 ^d	3.2 ± 0.3 ^d	0.0001	ns	ns
Total SCFA pool, mmol	69 ± 7 ^a	160 ± 14 ^b	184 ± 26 ^b	213 ± 20 ^b	215 ± 23 ^b	0.0001	0.016³	ns
Digesta pH	7.3 ± 0.1 ^c	6.3 ± 0.1 ^b	6.0 ± 0.1 ^ab	6.0 ± 0.1 ^ab	5.8 ± 0.1 ^a	0.0001	ns	ns
Faeces
Faecal output g/d	1.7 ± 0.1 ^a	3.0 ± 0.2 ^ab	3.7 ± 0.3 ^b	5.8 ± 0.6 ^c	8.3 ± 0.5 ^d	0.0001	0.028⁴	ns
Faecal fat², g/d	0.15 ± 0.02	0.09 ± 0.01	0.11 ± 0.02	0.09 ± 0.01	0.13 ± 0.01	ns	ns	ns

¹ Values are means ± SEM. Labelled means without a common letter differ, P < 0.05. ns = not significant, P > 0.05. All dietary treatments consist of n=8 obesity-prone and n=12 obesity-resistant rats.
²n=8 (n=4 obesity-prone and n=4 obesity-resistant rats per group).
³ obesity-prone 188 ± 11 mmol, obesity-resistant 149 ± 11 mmol.
⁴ obesity-prone 4.9 ± 0.5 g/d, obesity-resistant 4.3 ± 0.2.

ISSN: 1743-7075