Dietary resistant starch dose-dependently reduces adiposity in obesity-prone and obesity-resistant male rats

Nutrition & Metabolism

Table 5 Plasma lipids and gut hormones of obesity-prone and obesity-resistant rats after consuming diets with different levels of resistant starch for 4 wk ¹

	Resistant starch (RS), % of diet weight					Main Effects (P-value)
	0%	4%	8%	12%	16%	RS	Phenotype	RS x Phenotype
Triglycerides², mmol/L	1.4 ± 0.1 ^c	1.1 ± 0.1 ^bc	0.8 ± 0.1 ^ab	0.9 ± 0.1 ^ab	0.7 ± 0.1 ^a	0.0001	ns	ns
Free fatty acids², mmol/L	0.30 ± 0.02	0.29 ± 0.02	0.32 ± 0.03	0.34 ± 0.04	0.30 ± 0.03	ns	ns	ns
Total cholesterol², mmol/L	1.8 ± 0.1 ^c	1.8± 0.1 ^bc	1.6 ± 0.1 ^ab	1.5 ± 0.1 ^ab	1.5 ± 0.1 ^a	0.002	ns	ns
Leptin³, μg/L	14.7 ± 4.7 ^b	11.7 ± 1.1 ^ab	7.3 ± 4.5 ^a	8.3 ± 0.9 ^ab	5.3 ± 0.8 ^a	0.027	0.042⁴	ns
GLP-1³, pg/mL	29 ± 4 ^a	47 ± 4 ^ab	70 ± 7 ^bc	76 ± 6 ^bc	95 ± 23 ^c	0.0001	ns	ns
PYY³, pg/mL	71 ± 14 ^a	137 ± 11 ^ab	230 ± 30 ^bc	222 ± 22 ^bc	297 ± 54 ^c	0.0001	ns	ns
GIP³, pg/mL	372 ± 57 ^a	165 ± 29 ^b	134 ± 25 ^b	176 ± 52 ^b	81 ± 18 ^b	0.001	ns	ns

¹ Values are means ± SEM. Labelled means without a common letter differ, P < 0.05. ns = not significant, P > 0.05. GLP-1; glucagon-like peptide −1, PYY; polypeptide Y, GIP; gastric inhibitory peptide.
²n=16 (Obesity-prone; n=8, Obesity-resistant; n=8).
³n=8 (Obesity-prone; n=4, Obesity-resistant; n=4).
⁴ obesity-prone 11.7 ± 1.7 μg/L, obesity-resistant 7.3 ± 1.1 μg/L.

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