Figure 1

Effect of APOB ins/del polymorphism on postprandial triacylglycerol (TAG) and insulin response. A. Mean (SEM) for the postprandial TAG response in the APOB del/del (n = 52, open circles), del/ins (n = 70, open squares) and ins/ins (n = 25, open triangles) genotype groups after consumption of a test breakfast (49 g fat) at 0 min and a test lunch (29 g fat) at 330 min. There was a 44% and 31% higher TAG area under the curve (AUC) (del/del vs ins/del, P = 0.010; del/del vs ins/ins, P < 0.001; ins/del vs ins/ins, P < 0.001) in the ins/ins than del/del homozygotes and ins/del heterozygotes, respectively. B. Mean (SEM) for the AUC for the postprandial TAG response in men and women in the APOB del/del (white bars; n = 36 men/n = 16 women), del/ins (black bars; n = 51 men/n = 17 women) and ins/ins (dotted bars; n = 23 men/n = 2 women) genotype groups. There was a significant effect of genotype on the TAG AUC in men only (P = 0.043, del/del vs ins/del; P < 0.001, ins/ins vs both del/del and ins/del) whereas differences between genotypes were not evident in women (P > 0.501). C. Mean (SEM) for the postprandial insulin response in the APOB del/del (n = 10, open circles), del/ins (n = 15, open squares) and ins/ins (n = 10, open triangles) genotype groups after consumption of a test breakfast (49 g fat) at 0 min and a test lunch (29 g fat) at 330 min. There was a 69% higher AUC in the ins/ins than ins/del (P = 0.004) and del/del (P = 0.032) groups.