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Table 2 Fasting metabolites and postprandial measures according to the APOB insertion/deletion polymorphism in the study participants

From: The APOB insertion/deletion polymorphism (rs17240441) influences postprandial lipaemia in healthy adults

Participant characteristics Del/Del (n = 52) Ins/Del (n = 70) Ins/Ins (n = 25) Overall P value*
Age (y) 52 ± 2 56 ± 1 53 ± 2 0.176
Gender (men/women) 36/16 53/17 23/2 0.090
Body mass index (kg/m2) 26.6 ± 0.4 27.2 ± 0.4 27.9 ± 0.8 0.184**
Fasting metabolites     
Total cholesterol (mmol/l) 5.77 ± 0.12A 6.26 ± 0.11B 6.43 ± 0.21B 0.004
Triacylglycerol (mmol/l) 1.62 ± 0.09A 1.96 ± 0.10B 2.25 ± 0.14B 0.007
LDL-C (mmol/l) 3.75 ± 0.10A 4.24 ± 0.11B 4.32 ± 0.19B 0.007
HDL-C (mmol/l) 1.29 ± 0.04A 1.13 ± 0.03B 1.04 ± 0.04B 0.002
NEFA (μmol/l) 525.4 ± 31.5 503.5 ± 22.2 448.0 ± 22.1 0.079
Glucose (mmol/l) 5.23 ± 0.08 5.28 ± 0.07 5.39 ± 0.15 0.798
Insulin (pmol/l) 43.9 ± 3.37A 48.9 ± 4.08A 74.9 ± 12.3B 0.007
HOMA-IR 1.73 ± 0.14A 1.99 ± 0.18A 3.15 ± 0.57B 0.004
Postprandial summary measures     
Triacylglycerol (mmol/l × 480 min)     
AUC 1024.3 ± 52.5A 1268.9 ± 61.3B 1841.6 ± 135.4C <0.001
IAUC 273.3 ± 22.4A 326.0 ± 25.4A 511.6 ± 58.3B <0.001
NEFA (mmol/l × 300 min)¥     
AUC 160.0 ± 5.8 153.4 ± 6.2 149.8 ± 6.3 0.153
IAUC 94.8 ± 7.3 101.7 ± 3.9 91.3 ± 5.2 0.539
Glucose (mmol/l × 480 min)     
AUC 2979.1 ± 48.9 2946.9 ± 83.9 3184.9 ± 62.4 0.527
IAUC 489.9 ± 43.9 557.7 ± 31.4 533.3 ± 34.7 0.306
Insulin (nmol/l × 480 min)     
AUC 25.7 ± 8.6A 24.8 ± 6.1A 81.5 ± 23.0B 0.036
IAUC 113.2 ± 21.5 91.2 ± 9.8 172.8 ± 25.4 0.108
  1. Values represent mean ± SEM. Abbreviations: AUC area under the curve, HDL-C high density lipoprotein cholesterol, HOMA-IR homeostasis model assessment of insulin resistance, IAUC incremental area under the curve, LDL-C low density lipoprotein cholesterol, NEFA non-esterified fatty acids.
  2. Means with different superscript capital letters (A,B,C) denote significant differences between the Del/Del, Del/Ins and Ins/Ins genotypes (P < 0.05; see text for exact P values).
  3. Only 119 individuals had data for fasting insulin (n = 52 for del/del, n = 53 for del/ins and n = 14 for ins/ins) and n = 35 with postprandial insulin concentrations (n = 10 for del/del, n = 15 for del/ins and n = 10 for ins/ins).
  4. *Adjusted for age, gender and BMI.
  5. **Adjusted for age and gender.
  6. ¥AUC and IAUC for the NEFA response are calculated from the time of suppression (120 min) to the end of the postprandial period (480 min).