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Table 1 Kegg pathways enrichment P values in the differentially expressed gene sets

From: The beta-3 adrenergic agonist (CL-316,243) restores the expression of down-regulated fatty acid oxidation genes in type 2 diabetic mice

Pathway name P value MKR vs WT fat P value MKR vs WT liver P value MKR vs WT skeletal muscle P value prediabetic MKR vs WT liver P value CL treated MKR vs vehicle-treated MKR fat
Fatty acid biosynthesis 0.037 0.006 0.259 0.007 0.676
Fatty acid elongation 0.026 0.201 0.016 1.61E-05 0.731
Fatty acid degradation 1.79E-08 0.319 1.17E-05 3.31E-14 0.012
Synthesis and degradation of ketone bodies 0.381 0.422 0.103 5.27E-05 0.183
Steroid biosynthesis 0.060 0.081 0.002 9.23E-08 0.166
Primary bile acid biosynthesis 0.081 0.036 0.027 0.001 0.073
Steroid hormone biosynthesis 0.341 0.0008 0.097 0.001 0.114
Glycerolipid metabolism 8.45E-06 2.90E-05 1.98E-08 2.84E-08 7.49E-06
Fat digestion and absorption 0.181 0.244 5.40E-03 2.57E-05 6.86E-03
Glycerophospholipid metabolism 3.27E-12 9.99E-06 5.75E-08 2.22E-08 7.57E-09
Ether lipid metabolism 0.0004 0.002 0.002 0.0006 5.61E-07
Sphingolipid metabolism 0.079 0.0003 0.007 0.002 0.0003
Arachidonic acid metabolism 0.014 0.001 0.002 0.007 0.002
Linoleic acid metabolism 0.054 0.248 0.025 0.065 0.010
alpha-Linolenic acid metabolism 0.012 0.050 0.055 0.015 0.001
Biosynthesis of unsaturated fatty acids 0.085 0.006 0.055 3.35E-06 0.153