The beta-3 adrenergic agonist (CL-316,243) restores the expression of down-regulated fatty acid oxidation genes in type 2 diabetic mice

Table 5 Gene expression data for fatty acid oxidation pathway genes in liver from pre-diabetic MKR vs age-matched WT mice

Gene name	PD vs WT	Gene name	PD vs WT	Gene name	PD vs WT
EHHADH	−7.26916	ACOX3	−2.51966	ACSL1	NA
ALDH2	−6.37787	HSD17B4	−2.50286	ACSL5	NA
ALDH1A1	−5.94915	CPT2	−2.42769	ACSL6	NA
SLC27A5	−5.0653	ACAA2	−2.32958	ADH6A	NA
ALDH7A1	−4.70793	ACADL	−2.2378	ALDH1A2	NA
ACADVL	−4.33359	ACSL4	−2.20483	ALDH3A2	NA
ACOX1	−3.99613	ECHS1	−2.17225	CPT1A	NA
SLC27A4	−3.15579	HSD17B10	−2.08251	SDS	NA
ACSL3	−2.98288	ADH5	−2.02934	SLC27A1	NA
DCXR	−2.67591	ACAA1	NA	HSD17B8	NA
ADHFE1	−2.67386	ACADM	NA	SLC27A6	NA
ACAT1	−2.6477	ACSBG1	NA
IVD	−2.5505	ACSBG2	NA

NA corresponds to that gene expression data was not available in the cut-off dataset (Fold-change > 1.5X and p-value < 0.05). PD denotes prediabetic (3 week old MKR mice).

ISSN: 1743-7075