Figure 1

Relationship of plasma glucose and ketone body levels to brain cancer management. The glucose and ketone (β-­OHB) values are within normal physiological ranges under fasting conditions in humans. We refer to this state as the zone of metabolic management. As blood glucose falls and blood ketones rise, an individual is predicted to reach the zone of metabolic management. Tumor progression is predicted to be slower within the metabolic target zone than outside of the zone. This can be tracked utilizing the Glucose Ketone Index. The dashed lines signify the variability that could exist among individuals in reaching a GKI associated with therapeutic efficacy.