Skip to main content

Advertisement

Table 3 Estimates of aggregate desaturase indices (ADI) according to genotype for each SNP in Caucasian males

From: Ethnicity, sex, FADS genetic variation, and hormonal contraceptive use influence delta-5- and delta-6-desaturase indices and plasma docosahexaenoic acid concentration in young Canadian adults: a cross-sectional study

  n-3 ADI (EPA:ALA) n-6 ADI (AA:LA)
MM Mm mm p-value MM Mm mm p-value
  ADI SEM ADI SEM ADI SEM   ADI SEM ADI SEM ADI SEM  
FADS1               
rs174547 1.130 0.110 0.841 0.083 0.569 0.083 0.23 0.234a 0.008 0.182b 0.007 0.146b 0.146 1.57 × 10−6*
FADS2               
rs174570 0.971 0.081 0.784 0.069 0.428   0.73 0.214a 0.006 0.180b 0.010 0.111a,b   0.02
rs174576 1.153 0.117 0.818 0.081 0.604 0.072 0.12 0.235a 0.008 0.194b 0.007 0.156b 0.015 0.10 × 10−3*
rs174579 1.026 0.089 0.766 0.073 0.629 0.165 0.14 0.216 0.006 0.188 0.010 0.149 0.029 0.07
rs174593 1.044 0.092 0.823 0.096 0.680 0.099 0.19 0.221a 0.007 0.188b 0.008 0.181a,b 0.023 0.02
rs174602 0.997 0.087 0.880 0.104 0.657 0.092 0.23 0.216 0.008 0.193 0.008 0.177 0.020 0.04
rs174611 1.088 0.112 0.802 0.063 0.679 0.114 0.02 0.228a 0.007 0.187b 0.008 0.164b 0.020 4.31 × 10−6*
rs174626 1.089 0.112 0.916 0.112 0.791 0.079 0.19 0.232a 0.010 0.203a,b 0.008 0.179b 0.009 3.20 × 10−3
rs174627 1.017 0.085 0.761 0.076 0.567 0.100 0.12 0.216a 0.006 0.186b 0.010 0.108b 0.022 3.90 × 10−3
rs17831757 0.957 0.077 0.829 0.077 0.842 0.605 0.40 0.211 0.006 0.185 0.010 0.149 0.059 0.03
rs2072114 0.971 0.077 0.872 0.119 0.487 0.024 0.80 0.216a 0.007 0.183b 0.009 0.164a,b 0.004 5.10 × 10−3
rs2851682 0.967 0.077 0.824 0.094 0.237   0.57 0.212 0.006 0.182 0.009 0.090   0.02
rs482548 0.903 0.062 1.096 0.227 0.494   0.71 0.202 0.006 0.219 0.013 0.192   0.39
rs498793 0.871 0.103 0.936 0.075 1.041 0.183 0.32 0.195 0.009 0.207 0.009 0.219 0.012 0.43
rs526126 1.042 0.089 0.765 0.074 0.514 0.053 0.01 0.219a 0.006 0.186b 0.010 0.145b 0.011 1.90 × 10−3
rs968567 1.026 0.083 0.720 0.078 0.467   0.15 0.216a 0.006 0.182b 0.010 0.130a,b   0.03
  1. Results of analysis of 16 SNP from the FADS cluster for associations with n-3 and n-6 ADI. Different letters (a or b) denote values that are significantly different between groups. The * denotes p-values which are significant and withstood multiple testing. P-values were determined using multiple linear regression models which were adjusted for BMI, age, dietary LA, ALA, EPA and DHA, % total energy from dietary fat and physical activity. Abbreviations: M major, m minor, ADI aggregate desaturase indices, SEM standard error of the mean.