Skip to main content

Table 6 Estimates of aggregate desaturase indices (ADI) according to genotype for each SNP in East Asian females

From: Ethnicity, sex, FADS genetic variation, and hormonal contraceptive use influence delta-5- and delta-6-desaturase indices and plasma docosahexaenoic acid concentration in young Canadian adults: a cross-sectional study

 

n-3 ADI (EPA:ALA)

n-6 ADI (AA:LA)

MM

Mm

mm

p-value

MM

Mm

mm

p-value

 

ADI

SEM

ADI

SEM

ADI

SEM

 

ADI

SEM

ADI

SEM

ADI

SEM

 

FADS2

              

rs174579

0.932

0.052

0.869

0.123

0.519

0.178

0.53

0.183

0.006

0.158

0.005

0.130

0.009

0.03

rs174593

0.940

0.052

0.849

0.125

0.587

0.154

0.57

0.183a

0.006

0.156b

0.005

0.131a,b

0.008

0.01

rs174602

0.995

0.072

0.867

0.081

0.797

0.122

0.27

0.199a

0.009

0.163b

0.003

0.148b

0.006

4.11 × 10−5*

rs174626

0.996

0.070

0.798

0.053

0.986

0.254

0.20

0.194a

0.009

0.162b

0.004

0.154b

0.007

0.30 × 10−3*

rs2072114

1.068a

0.100

0.889a,b

0.064

0.695b

0.086

0.01

0.209a

0.011

0.165b

0.003

0.142b

0.004

7.80 × 10−8*

rs2845573

1.065a

0.100

0.887a,b

0.063

0.702b

0.087

0.03

0.209a

0.011

0.165b

0.003

0.142b

0.004

3.82 × 10−7*

rs2851682

1.061a

0.100

0.886a,b

0.064

0.712b

0.087

0.04

0.208a

0.011

0.165b

0.0003

0.144b

0.005

1.24 × 10−6*

rs498793

0.925

0.055

0.802

0.108

1.177

0.614

0.55

0.177

0.006

0.165

0.006

0.203

0.016

0.35

rs526126

0.935

0.065

0.862

0.074

0.844

0.198

0.68

0.183

0.007

0.163

0.004

0.151

0.010

0.16

  1. Results of analysis of 9 SNP from the FADS cluster for associations with n-3 and n-6 ADI. Different letters (a or b) denote values that are significantly different between groups. The * denotes p-values which are significant and withstood multiple testing. P-values were determined using multiple linear regression models which were adjusted for BMI, age, dietary LA, ALA, EPA and DHA, % total energy from dietary fat and physical activity. Abbreviations: M major, m minor, ADI aggregate desaturase indices, SEM standard error of the mean.