Fig. 4
From: E2F8 promotes hepatic steatosis through FABP3 expression in diet-induced obesity in zebrafish
Effects on fabp3, e2f3 and e2f8 morpholino in DIO-zebrafish. (a) E2f8 Western blot of MO-e2f8 and control MO administration in HF. n = 3, *P < 0.05. (b-c) MO i.p. administration did not affect body weight (a) and body length (b) in DIO-zebrafish on day 14. MO-con indicates control MO as a negative control. n = 5, *P < 0.05 vs. NF. (d) MO i.p. administration did not affect plasma TG in DIO-zebrafish on day 14. n = 5, *P < 0.05 vs. NF. (e) MO-fabp3 i.p. administration increased the level of fasting blood glucose, while HF + control MO (MO-con) did not. n = 5, *P < 0.05 vs. NF. (f) The area of lipid droplets of Oil Red O staining of liver. All MOs suppressed liver steatosis in DIO-zebrafish. n = 5, *P < 0.05 vs. NF, #P < 0.05 vs. HF+ MO-con