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Fig. 3 | Nutrition & Metabolism

Fig. 3

From: A novel anti-inflammatory natural product from Sphaeranthus indicus inhibits expression of VCAM1 and ICAM1, and slows atherosclerosis progression independent of lipid changes

Fig. 3

a Sphaeranthus Indicus extract inhibits lipopolysaccharide-induced TNF-α production in mice. Groups of 10 mice were treated orally with Sphaeranthus Indicus methanolic extract, 60 min prior to lipopolysaccharide injection (1 mg/kg, i.p.). Levels of TNF-α in the plasma were measured 1.5 h after lipopolysaccharide injection. Results are expressed as the mean ± S.E.M. *P < 0.001 significantly different from LPS control (students t test). b Sphaeranthus indicus extract inhibits lipopolysaccharide-induced IL-1β production in mice. Groups of 10 mice were treated orally with S. indicus 60 min prior to lipopolysaccharide injection (2 mg/kg, i.p.). Amounts of IL-1β in the plasma were measured 4 h after lipopolysaccharide injection. Results are expressed as the mean ± S.E.M. *P < 0.001 significantly different from LPS control (students t test)

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