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Fig. 1 | Nutrition & Metabolism

Fig. 1

From: Ammonia-lowering activities and carbamoyl phosphate synthetase 1 (Cps1) induction mechanism of a natural flavonoid

Fig. 1

Nobiletin (NOB) lowers serum ammonia levels. a Body weight change of wild-type (WT) mice fed with regular chow (RC) or high-fat diet (HFD) and treated with either vehicle (Veh) or Nobiletin (NOB) for 10 weeks (n = 11–12). ***p < 0.001. b Serum ammonia levels at Zeitgeber Time (ZT) 6 and 18 in the mice described in (a). ZT0 corresponds to the onset of light phase. c Body weight change of WT mice fed with RC or high-protein diet (HPD) and treated with either Veh or NOB for 4 weeks (n = 6–7). d Serum ammonia levels at ZT6 and ZT18 in the mice described in (c). Data are presented as mean ± SEM. For panels b and d, Student’s t-test: Veh vs. NOB, **p < 0.01, ***p < 0.001; RC vs. HFD or HPD, ††p < 0.01

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