Fig. 1

The body weight and energy intake of the five groups during the experiment. Male C57BL/6 mice were fed either NC or HF for 8 weeks beginning at age 4 weeks, then they were divided into five groups: NC AL, NC CR (40 % CR), HF AL, HF → NC, HF → NC CR (40 % CR), these treatments continued for another 3 weeks. a the body weight and (b) energy intake were evaluated throughout the experimental period. Data were presented as means ± SE, n = 20. a indicates P < 0.05 versus NC AL group; b indicates P < 0.05 versus HF AL group. Abbreviations: NC, normal chow; HF, high-fat diet; AL, ad libitum; CR, calorie restriction