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Fig. 4 | Nutrition & Metabolism

Fig. 4

From: Moderate calorie restriction to achieve normal weight reverses β-cell dysfunction in diet-induced obese mice: involvement of autophagy

Fig. 4

Effects of CR on glucose tolerance, early-phase and second-phase insulin secretion and insulin sensitivity. Blood glucose (a) and plasma insulin (b) were measured at times 0, 15, 30, 60, and 120 min in response to a glucose challenge (i.p. 2 g/kg) in 16-h fasted conscious mice. Data were presented as means ± SE, n = 6–8 mice/group. a indicates P < 0.05 versus NC AL group; b indicates P < 0.05 versus HF AL group. Abbreviations: i.p., intraperitoneally; AUC, area under the curve; HOMA-IR, homeostasis model assessment of insulin resistance

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Nutrition & Metabolism

ISSN: 1743-7075

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