Skip to main content
Fig. 4 | Nutrition & Metabolism

Fig. 4

From: Quercetin reduces obesity-induced hepatosteatosis by enhancing mitochondrial oxidative metabolism via heme oxygenase-1

Fig. 4

Effect of an HO-1 inducer and/or CO on hepatic lipid accumulation and mitochondrial oxidative metabolism in HFD-fed mice (a-c) C57BL/6 mice were fed an HFD diet for 2 weeks with hemin injection three times per week (n = 5 per group). a Liver tissues were collected and their TG contents were determined. b PGC-1α, Nrf-1, and Tfam mRNAs were quantified by real-time PCR. c Expression levels of COX IV protein was determined by Western blotting. Data are mean ± SEM of five mice per group. *p < 0.05 versus HFD. d-f C57BL/6 mice inhaled CO (250 ppm) for 2 h each day for 10 weeks (n = 6–7 per group). d Liver tissues were collected and their TG contents were determined. e PGC-1α, Nrf-1, and Tfam mRNAs were quantified by real-time PCR. f Expression levels of COX IV protein were determined by Western blotting. Data are mean ± SEM of six to seven mice per group. *p < 0.05, # p < 0.005 versus HFD

Back to article page