Fig. 4
Hepatic S1P KD and regulators of the LDLR. a and b: Hepatic mRNA analyses in S1Pf/fLuci and S1Pf/fCre mice using real-time PCR. a, Idol; b, ARH; c and d: studies in the mouse models of Fig. 2: c, PCSK9 mRNA levels; d, Plasma PCSK9 protein levels quantified using ELISA. N = 4, each data point represents the mean +/- SD * denotes p < 0.05. ns denotes not significant