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Table 1 Phenotypic comparison of S1Pf/f, and LDLR-/-S1Pf/f after hepatic S1P KD

From: Hepatic S1P deficiency lowers plasma cholesterol levels in apoB-containing lipoproteins when LDLR function is compromised

Parameter S1Pf/f LDLR-/-S1Pf/f
Ad-Luci Ad-Cre Ad-Luci Ad-Cre
Number and sex 4 females 4 females 4 females 4 females
S1P mRNA %a 100 ± 7.8 23.3 ± 3.0** 100 ± 3.8 29 ± 15.4**
TC, mg/dl 78.5 ± 13.2 43.7 ± 7.0* 180.8 ± 31.9 109.9 ± 14.4*
TG, mg/dl 111.2 ± 20.5 69.5 ± 7.0* 107.3 ± 36.9 73.8 ± 16.6*
  1. Female mice (6–8 weeks of age) were injected i.v. with either Ad-Luci or Ad-Cre as described in Methods. Eight days after the last injection, blood was obtained. Each value represents the mean ± the SD of four mice. The statistical significance (Student’s t test) between Ad-Luci and corresponding Ad-Cre mice was calculated. *P < 0.05; and **P < 0.01. afull length S1P mRNA expression is expressed as a % of the corresponding Ad-Luci value