Hepatic S1P deficiency lowers plasma cholesterol levels in apoB-containing lipoproteins when LDLR function is compromised

Table 1 Phenotypic comparison of S1P^f/f, and LDLR^-/-S1P^f/f after hepatic S1P KD

Female mice (6–8 weeks of age) were injected i.v. with either Ad-Luci or Ad-Cre as described in Methods. Eight days after the last injection, blood was obtained. Each value represents the mean ± the SD of four mice. The statistical significance (Student’s t test) between Ad-Luci and corresponding Ad-Cre mice was calculated. *P < 0.05; and **P < 0.01. ^afull length S1P mRNA expression is expressed as a % of the corresponding Ad-Luci value

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