|
Parameter
|
S1Pf/f
|
LDLR-/-S1Pf/f
|
|---|
|
Ad-Luci
|
Ad-Cre
|
Ad-Luci
|
Ad-Cre
|
|---|
|
Number and sex
|
4 females
|
4 females
|
4 females
|
4 females
|
|
S1P mRNA %a
|
100 ± 7.8
|
23.3 ± 3.0**
|
100 ± 3.8
|
29 ± 15.4**
|
|
TC, mg/dl
|
78.5 ± 13.2
|
43.7 ± 7.0*
|
180.8 ± 31.9
|
109.9 ± 14.4*
|
|
TG, mg/dl
|
111.2 ± 20.5
|
69.5 ± 7.0*
|
107.3 ± 36.9
|
73.8 ± 16.6*
|
- Female mice (6–8 weeks of age) were injected i.v. with either Ad-Luci or Ad-Cre as described in Methods. Eight days after the last injection, blood was obtained. Each value represents the mean ± the SD of four mice. The statistical significance (Student’s t test) between Ad-Luci and corresponding Ad-Cre mice was calculated. *P < 0.05; and **P < 0.01. afull length S1P mRNA expression is expressed as a % of the corresponding Ad-Luci value
