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Table 2 Phenotypic comparison of S1Pf/f and L-S1P

From: Hepatic S1P deficiency lowers plasma cholesterol levels in apoB-containing lipoproteins when LDLR function is compromised

Parameter S1Pf/f L-S1P
Number and sex 5 males 5 males
S1P mRNA %a 100 ± 39.2 15 ± 8.4**
TC, mg/dl 68.8 ± 6.3 49.7 ± 5.3*
TG, mg/dl 52.7 ± 10.7 36.9 ± 7.5*
  1. Blood was obtained from non-fasted male mice (6–8 weeks of age) as described in Methods. Each value represents the mean ± the SD of five mice. The statistical significance (Student’s t test) between S1Pf/f and L-S1P was calculated. *P < 0.05; and **P < 0.01. afull length S1P mRNA expression is expressed as a % of the corresponding S1Pf/f value
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Nutrition & Metabolism

ISSN: 1743-7075

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